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Chem. Rev. 综述-“Magnetic Nanoparticles”-磁性纳米颗粒的合成及生物应用
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 磁性纳米材料是纳米领域的研究热点之一。精确控制合成条件和表面修饰对磁性纳米颗粒而言是非常重要的，因为它会决定材料的物理化学属性，进而决定其应用。本文综述了磁性纳米材料的合成方法、物理化学特征及其在生物医药方面的应用。全文61页，引文710篇。 1. Introduction 2. Design of Magnetic Colloids 2.1. Synthesis Strategies 2.1.1. Electron Beam Lithography 2.1.2. Gas-Phase Deposition 2.1.3. Sol–Gel Method 2.1.4. Oxidation Method 2.1.5. Chemical Coprecipitation 2.1.6. Hydrothermal Method 2.1.7. Flow Injection Method 2.1.8. Electrochemical Method 2.1.9. Aerosol/Vapor-Phase Method 2.1.10. Sonochemical Decomposition Method 2.1.11. Supercritical Fluid Method 2.1.12. Synthesis Using Nanoreactors 2.1.13. Microbial Method 2.1.14. Synthesis of Metal-Doped Iron Oxide Nanoparticles 2.2. Stabilization Procedures 2.2.1. Use of Stabilizing Surface Coating Materials 2.2.2. Encapsulation into Polymeric Shells 2.2.3. Encapsulation into Liposomes 3. Physicochemical Properties and Physicochemical Characterization 3.1. Geometry 3.2. Structure 3.3. Surface Charge 3.4. Surface Thermodynamics 3.5. Magnetism 3.6. Colloidal Stability 4. Pharmacokinetics, Biodistribution, And Biological Fate 4.1. Influence of the Size 4.2. Influence of the Surface Charge 4.3. Influence of the Administration Route 4.4. Factors Influencing the Tissue/Cell Penetration 5. Toxicity and Biocompatibility 5.1. In Vitro Evaluation of the Toxicity 5.1.1. Influence of the Surface Coatings 5.1.2. Influence of the Size 5.1.3. Influence of the Surface Charge 5.2. In Vivo Evaluation of the Toxicity 5.2.1. Toxicity after Intravenous Administration 5.2.2. Toxicity after Intraperitoneal Administration 5.2.3. Toxicity after Subcutaneous Administration 6. Disease Therapy 6.1. Construction of Magnetically Guided Nanoparticles for Drug Delivery 6.2. Chemotherapy 6.2.1. Systemic Chemotherapy 6.2.2. Local Chemotherapy 6.2.3. Oral Delivery 6.2.4. Stimuli-Sensitive Drug Delivery 6.2.5. Miscellaneous Applications 6.3. Magnetofection (Gene Delivery) 6.3.1. In Vitro Magnetofection 6.3.2. In Vivo Magnetofection 6.4. Magnetically Guided Radioimmunotherapy 6.5. Magnetically Guided Photodynamic Therapy 6.6. Magnetic Fluid Hyperthermia 6.6.1. Preclinical Evaluation of Magnetic Fluid Hyperthermia 6.6.2. Clinical Evaluation of Magnetic Fluid Hyperthermia 7. Magnetic Resonance Imaging 7.1. Organ/Tissue Imaging 7.1.1. Lymph Node Imaging 7.1.2. Imaging of Atherosclerotic Plaques 7.1.3. Imaging of Inflammatory Response in Central Nervous System Disorders 7.1.4. Imaging of Macrophage Infiltration in Transplanted Organs 7.1.5. Imaging of Macrophage Infiltration in Knee Joints 7.1.6. Imaging Using Ligand-Functionalized Superparamagnetic Iron Oxide Nanoparticles 8. Cell Labeling and Imaging 8.1. Imaging of Transplanted Stem Cells 8.2. Imaging of Transplanted Pancreatic Islet Cells 8.3. Imaging of Dendritic Cells 8.4. Imaging of Apoptotic Cells 9. Tissue Engineering 9.1. Engineering of Heterotypic Cell/Tissue Constructs 9.2. Scaffold-Based Tissue Engineering 9.3. Scaffold-Free Engineering of Three-Dimensional Tissue Constructs 10. Miscellaneous Applications 10.1. Cell Separation and Cell Sensing 10.1.1. Separation of Bacterial Cells And Mammalian Cells 10.1.2. Separation of Viruses 10.1.3. Magnetic-Relaxation Switches 10.2. Separation of Biochemicals 10.3. Enzyme/Protein Immobilization 10.4. Bioanalysis and Immunoassays 10.5. Separation of Heavy Metal Contaminants from Mixtures 11. ConclusionsMagnetic Nanoparticles.jpg [ Last edited by dut_ameng on 2012-10-10 at 09:47 ] |
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