| 查看: 405 | 回复: 1 | ||
zclovegirl金虫 (小有名气)
|
[求助]
求助文献 Amylin-its physiological role in humans
|
| 求助文献 Amylin-its physiological role in humans |
回复此楼» 猜你喜欢
达托霉素杂质61
已经有0人回复
-
阿维菌素杂质3(阿维菌素A2a)
已经有0人回复
-
遗传学与生物信息学论文润色/翻译怎么收费?
已经有281人回复
-
阿维菌素
已经有0人回复
-
求国考税务机关招考面试辅导
已经有0人回复
-
求调剂
已经有1人回复
-
硫胺素杂质93
已经有0人回复
-
340求调剂（一志愿：临检学硕）
已经有0人回复
-
异丁基(1-苯基丙烷-2-基)氨基甲酸酯
已经有0人回复
-
枸橼酸托法替布杂质331
已经有0人回复
whding9266
金虫 (正式写手)
- 应助: 19 (小学生)
- 金币: 653.6
- 红花: 1
- 帖子: 310
- 在线: 27.8小时
- 虫号: 2070727
- 注册: 2012-10-18
- 性别: MM
- 专业: 心脏结构与功能异常
【答案】应助回帖
|
Abstract Amylin is a polypeptide hormone composed of 37 aminoacids, that is produced in pancreatic beta-cells, and that was discovered in 1987. Releasing amylin into the circulation is increased postprandially, proportionally to the amount of digested food. Daily profile of amylin plasma levels corresponds to the profile of insulin. Normal plasma levels of amylin vary from 4 pmol/L (fasting) to 25 pmol/L (postprandially). Receptors for amylin are highly concentrated especially in the central nervous system--area postrema and nucleus accumbens. There is a 20% sequence homology between amylin, calcitonin and adrenomedullin and 44% homology with calcitonin gene--related peptide. Amylin contributes to the regulation of postprandial glycaemia by suppression of glucagon release and by regulation of gastric emptying. Deficit os amylin is typical for diabetes mellitus type 1 or for the late stage of diabetes type 2. Insulin resistance in obese patients is characterized by increased levels of both insulin and amylin. Amylin decreases food intake and participates in the regulation of body weight. Some biochemical forms of amylin cause proliferation of osteoblasts and inhibit bone resorption. Amylin modulates insulin sensitivity of skeletal muscle, contributes to the regulation of blood pressure and causes vasodilatation. 抱歉，搞不到全文。 |
2楼2012-10-22 06:36:20