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[求助]
求助翻译一段英文摘要，非常感谢，在线等，急求
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Vasopressin V2 Receptor Blockade With Tolvaptan Versus Fluid Restriction in the Treatment of Hyponatremia Hyponatremia is common and is associated with a poor prognosis.Traditional management with fluid restriction is difficult to maintain,and it is often ineffective. The objective of this study was to determine the effect of tolvaptan versus fluid restriction on serum sodium concentration.The study was a prospective,multicenter, randomized,active-controlled,open-label trial.Twenty-eight hospitalized subjects with serum sodium<135 mmol/L were enrolled in the study.After a 2-day run-in period,subjects were randomized 2:1 to tolvaptan alone(n 17)or fluid restriction (1,200 ml/day)plus placebo(n 11).Oral tolvaptan was started at 10 mg/day and increased to 60 mg/day as needed.Treatment was continued for up to 27 days,and follow-up continued for up to 65 days.The primary end point was the normalization of serum sodium,defined as>135 mmol/L or a>10%increase from baseline.At the last inpatient visit,serum sodium had increased by 5.7 3.2 mmol/L in the tolvaptan group and 1.0 4.7 mmol/L in the fluid restriction group(p 0.0065).No differences in adverse events were observed between the groups.In conclusion,tolvaptan appears to be more effective than fluid restriction at correcting hyponatremia in hospitalized subjects,without an increase in adverse events. [ Last edited by ?? on 2012-10-9 at 11:29 ] |
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yangboa007
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| 可以先用百度翻译初步翻译一下，然后再逐步对照就行了哦！这是百度翻译地址：https://fanyi.baidu.com/；或者用谷歌翻译也行，不过我觉得百度翻译好用一点，更符合国人的思路。谷歌翻译具体地址：https://translate.google.cn/ |
2楼2012-10-09 16:51:58
