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高暴露地区母婴血液中多溴联苯醚代谢产物及潜在风险研究 基本信息 批准号20807003 项目名称高暴露地区母婴血液中多溴联苯醚代谢产物及潜在风险研究 项目类别青年科学基金项目 申请代码B070704 项目负责人邱兴华 负责人职称研究员 依托单位北京大学 研究期限2009-01-01 到 2011-12-31 资助经费20.0000（万元） 项目摘要 中文摘要 环境污染物暴露是影响人体健康的重要因素，而建立污染物暴露与健康效应的联系是控制污染物排放以保护人体健康的理论依据。本研究一方面选择典型的污染区域（电子垃圾拆解场），筛选典型的污染物并评价其健康效应。研究发现电子垃圾场地区人体血液中电子垃圾相关的持久性有机污染物如PCBs、低溴代PBDEs、BB-153、Dechlorane Plus等均显著高于对照地区，是后者的2-8倍。与此相应的是，电子垃圾场地区人体遗传损伤显著高于对照地区，体内氧化应激、免疫功能等由污染物导致的健康效应均显示该地区人群具有更高的健康风险包括肿瘤风险。另外一方面以健康效应（神经管畸形）为出发点，研究持久性有机污染物暴露的与神经管畸形发生的关系，发现当暴露于较高浓度PAHs等污染物时，胎儿发生神经管畸形的风险增加并具有显著的剂量-反应关系。本研究表明，污染物尤其是持久性有机污染物暴露对人体健康有重要影响；进一步的分子水平的机理研究将有利于揭示污染物暴露的健康效应机制。 中文主题词电子垃圾拆解场，持久性有机污染物，健康效应，肿瘤风险，神经管畸形 英文摘要 Human's exposure to environmental pollutants and the consequent health effects are important scientific issues. In this project we chose electronic-waste (e-waste) recycling site as typical polluted region and measured persistent organic pollutants in human blood to explore their health effects. We found that e-waste related pollutants, inlcuding PCBs, lower brominated PBDEs, BB-153, and Dechlorane Plus in blood samples from people working or living in the e-waste site were 2-8 folds higher than in those from a control region. Correspondingly, biomarkers of health effects, including geneic damage, oxidative stress, immune function, and so on, all insinuated a higher health risk especially the risk of tumour for people working or living in the e-waste site. On the other hand, we explored the risk factors of a certain health outcome, i.e., neural tube defects, by measuring persistent organic pollutants including PBDEs, PCBs, PAHs, and pesticides in placentas as indicator of fetus/infant prenatal exposure. We found that when exposed to higher levels of PAHs and some pesticides, the risk of neural tube defects significantly increased with dose-response relationship. These studies provided a preliminary view on the relationship between exposure to pollutants and the health effects, and further research on molecular level is warranted to reveal the mechanism of health effects caused by pollutants. 英文主题词e-waste recycling site，persistent organic pollutants, health effects, risk of tumour, neural tube defects |
2楼2014-04-15 12:09:52