²é¿´: 8357  |  »Ø¸´: 156
µ±Ç°Ö÷ÌâÒѾ­´æµµ¡£

fhang0427

ľ³æ (ÕýʽдÊÖ)

[½»Á÷] ¡¾×ªÌù¡¿ÃÉţвúÆ·¡°ÌØÂ×ËÕ¡±Ö°©¡¾ÒÑËÑÎÞÖØ¸´¡¿

×î½üÔÚÒ»¸öblogÉÏ¿´µ½ÃÉÅ£¡°ÌØÂ×ËÕ¡±Ö°©µÄÎÄÕ£¬ÎÒÒ²²éÁËÃÉÅ£µÄרÀû(20061000355.9)ÆäIGF-1º¬Á¿È·ÊµÖ°©£¨²»ÐÅ¿ÉÒÔ×Ô¼º²éרÀû£©£¬ÃÉţʵÔÚÌ«²»ºñµÀÁË£¬ÎªÁËÕõÇ®²»¹Ë´ó¼ÒµÄÉíÌ彡¿µ£¬ÎªÁ˹ã´óÅóÓѼ°ÅóÓѵļÒÈ˺ÍÅóÓѵĽ¡¿µÌØ·¢´ËÌù¡£

¾õµÃºÃµÄÅóÓÑÇë°ïÎÒ¶¥Ò»Ï¡£

Ҳ̸ÃÉÅ£¡°ÌØÂ×ËÕ¡±Å£ÄÌÖеġ°Ôì¹ÇÅ£Ä̵°°×¡±
¡¡¡¡ ¡ª¡ªÒȵºËØÑùÉú³¤Òò×Ó-1£¨IGF-1£©¿ÉÒý·¢¶àÖÖ°©Ö¢


¡¡¡¡ÔÚ¹úÍâ¿´µ½¹úÄÚµÄвúÆ·£¬Ð·¢Ïֵı¨µÀ£¬±¾¸ÃÂúÐÄ»¶Ï²²ÅÊÇ¡£µ«Êµ¼ÊÉÏÓÐʱÊÇÓÇÐÄâçâ磬ÓÐʱÊÇ¿ÞЦ²»µÃ£¬ÓÐʱÊDZ¯?ÄÖÐñ磬ÓÐʱÔòÊÇÂúǻŭ»ð¡£ÒòΪÓеÄÊDZ¨µÀʧʵ£¬ÓÐÒâÔì¼Ù£¬×ÔÎÒ´µÐ꣬ƭȡ¹ú¼Ò¿ÆÑ§»ù½ð£»ÓеÄÊÇÓÐÒâÎóµ¼£¬ÆÛÂ÷ºöÓÆÄÇЩÐĵØÉÆÁ¼£¬µ«È±·¦¿ÆÑ§ÖªÊ¶£¬Ò×ÓÚÇáÐÅ¹ã¸æ£¬ÃûÈË£¬Ã½Ì壬ר¼Ò£¬Ñ§ÕßµÄÉÆÁ¼ÀϰÙÐÕ¡£Î廨°ËÃÅ£¬Ó¦Óо¡ÓУ¡¶¼ÊÇΨÀûÊÇͼÃÁ×ÅÁ¼ÐĵÄÐû´«£¡Èç×î½ü±»³´µÃ·Ð·ÐÑïÑïµÄÃÉţвúÆ·¡°ÌØÂ×ËÕ¡±Å£ÄÌÖеġ°Ôì¹ÇÅ£Ä̵°°×¡± £¨OMP£©¡£¼¸ÄêǰÎÒÔøÑо¿Óë¹Ç÷ÀÓйصĿÎÌ⣬´ÓÀ´Ã»Óмûµ½¹ý¡°Ôì¹ÇÅ£Ä̵°°×¡±µÄ±¨µÀ£¬ÓйصĹú¼ÊѧÊõ»áÒéÉÏҲûÓÐÌýµ½¹ýÕâ·½ÃæµÄÏûÏ¢¡£Èç¹ûÊǽüÒ»£¬¶þÄêÀ´µÄз¢ÏÖ£¬¿ÖÅÂÁ¬×÷ÓûúÖÆ¶¼À´²»¼°¸ãÇå³þ£¬ÔõÄÜÕâô¿ì¾ÍÓõ½ÈËÉíÉÏ£¿ºóÀ´´Ó¡°ÐÂÓïË¿¡±É϶Áµ½·½ÖÛ×ÓµÈÈ˵ÄÎÄÕ£¬ÖÊÒÉ´ËÔì¹Çµ°°×²»ÊÇʲôз¢Ïֵĵ°°×ÖÊ£¬¶øÊǹúÄÚÍâ¶¼ÔçÒÑÊìÖªµÄÒȵºËØÑùÉú³¤Òò-1£¨IGF-1£©£¬Ö»²»¹ý¸ø»»Á˸öÃû³Æ¶øÒÑ¡£´ÓËûÒýÓõÄ÷·½È¨½ÌÊÚµÄ×ÊÁÏ£º¡°Ö÷Òª´æÔÚÓÚѪҺÖУ¬´ó²¿·ÖÓɸÎÔàºÏ³É¡£¡£¡£º¬ÓÐ70¸ö°±»ùËᣬ·Ö×ÓÁ¿Îª7649¡±¡££¬ÎÒÒ²ÈÏΪËüÊÇÒȵºËØÑùÉú³¤Òò-1¡£ÒòΪ°±»ùËáÊýÄ¿ºÍ·Ö×ÓÁ¿ÊýÖµ¶¼Ïàͬ£¬Ò»µã²»²î£¬Èô·ÇÒȵºËØÑùÉú³¤Òò- 1£¬ÄǾÍÊÇËüµÄ¡°Í¬·ÖÒì¹¹Ì塱ÁË¡£ÕâÖÖ¿ÉÄÜÐÔ¼«Ð¡¼«Ð¡¡£ÔÚÎÒ¶àÄêµÄÉúÎïҽѧÑо¿ÖУ¬»¹´ÓÀ´Ã»ÓÐÅöµ½¹ý¡£
¡¡¡¡ÖÊÒÉÎÄÕµdzöÒÑÒ»¸öÔÂÓ࣬Óеı¨Ö½¼ÇÕß»¹²É·Ã¹ýÃÉÅ£¹«Ë¾ºÍËüµÄÊ×ϯ¿ÆÑ§¼Òĸxx£¬ÖÁ½ñδ¼ûÃÉÅ£¹«Ë¾·¢±íÈκγöÀ´³ÎÇåµÄÎÄÕ»òÉêÃ÷£¬Õâ¾ÍÊÇ˵£ºÄ¬ÈÏ¡°Ôì¹ÇÅ£Ä̵°°×¡±¾ÍÊÇ¡°ÒȵºËØÑùÉú³¤Òò-1¡±¡£ÈôÊÇÈç´Ë£¬ÎÊÌâ¾ÍºÜÑÏÖØ¡£ÒòΪÒȵºËØÑùÉú³¤Òò-1£¨IGF-1£©ÄÜÒý·¢¶àÖÖ°©Ö¢¡£ÑªÒºÖÐIGF-1¸ßµÄÈË£¬Ò×»¼¶àÖÖÉÏÆ¤Ï¸°û°©
£¨1£¬2£¬17£©¡£³ýÁËÈéÏÙ°©£¨3£¬18£©Í⣬»¹»áÒý·¢Ç°ÁÐÏÙ°© (4-8)£¬·Î°© (10,13)ºÍ½á³¦Ö±³¦°©(14-16)¡£¿ÉÄÜ»¹Ôö¸ß»¼°òë×°©µÄ·çÏÕ£¨19£©¡£ÕâÑù£¬ºÈÁËÃÉÅ£¡°ÌØÂ×ËÕ¡±Å£Ä̾ͻá³öÏÖÁ©ÖÖ¿ÉÄÜÐÔ¡£µÚÒ»ÖÖÊǰ´ÕÕÃÉÅ£¹«Ë¾µÄÐû´«£¬IGF-1ÄÜÒÔÍêÕûÎÞȱµÄÐÎʽͨ¹ýÏû»¯µÀ£¬ÔÚÌåÄÚ·¢»ÓËùνµÄÔì¹Ç×÷Óᣵ«Êµ¼Ê½á¹ûÊÇÔì¹Ç²»³É£¨ÃÉÅ£¹«Ë¾Ã»ÓÐÖ¤Ã÷ËüµÄ£¨IGF-1£©¶ÔÈ˲ÅÌåÓÐÔöÇ¿¹ÇÃܶȣ¬´Ù½ø¹ÇÁ¿Ôö¼ÓµÄ×÷Ó㬼´Ê¹Óôó°×Êó×öµÄ¶¯ÎïÊÔÑ飬ҲûÓеõ½Ã÷È·µÄ½á¹û£©£¬·´¶øºÜ¶àÈË¿ÉÄܽ«»¼ÉÏǰÁÐÏÙ°©£¬»òÈéÏÙ°©£¬»ò·Î°©£¬»ò½á³¦Ö±³¦°©£¨ÕâÊÇ´óÁ¿¹ú¼ÊҽѧÑо¿³É¹ûÖ¤Ã÷Á˵ģ©ÒÔ¼°¿ÉÄܵİòë×°©¡£Õâ¾Í¼£½ü¡°Ä±²Æº¦Ãü¡±ÁË¡£µÚ¶þÖÖ½á¹ûÊÇĿǰÉúÎïҽѧ֪ʶËùÈÏΪµÄ£ººÈ½øµÄÔì¹ÇÅ£Ä̵°°×£¨IGF-1£©ÔÚ賦µÀÖб»Ïû»¯¡¢½µ½â£¬¶ø²»»á±»ÍêÕûµØÎüÊÕ½øÑªÒºÖУ¬ÖÁÉÙ¶ÔÐÂÉú¶ùÖ®ÍâµÄÆäËûÈËÊÇÈç´Ë£¨¼û·½ÖÛ×ÓÎÄ£©¡£ÄÇôËùνµÄ¡°Ôì¹ÇÅ£ÄÌ¡±Ö»²»¹ý²¹³äÁËһЩ°±»ùËᣨ»òһЩСëÄÆ¬¶Î£©¶øÒÑ¡£¾ÍÓëºÈÆÕͨµÄÅ£ÄÌÍêȫһÑù¡£½áÂÛÊÇ£º¡°ÌØÂ×ËÕ¡±Å£Ä̶ÔÈËÌå²»ÊÇÓк¦¾ÍÊÇÎÞÒæ£¬Ïû·ÑÕßǧÍò²»Äܹâ¹Ë£¬²»ÒªÉϵ±ÊÜÆ­¡£
¡¡¡¡Ð´µ½ÕâÀ²»½ûÒªÇëÎÊÃÉÅ£¹«Ë¾µÄÊ×ϯ¿ÆÑ§¼ÒĸÏÈÉú£ºÄúÃÇÐû³ÆOMPÊÇ¡°ÓÉÃÉÅ£ÈéÒµµÄ¿ÆÑÐÈËÔ±·¢ÏÖ²¢ÃüÃûµÄ¡±£¬ÕâÕæÊÇÒ»ÖÖз¢Ïֵĵ°°×ÖÊ£¿ÈôÊǵϰ£¬ÇëÎÊËüµÄ°±»ùËá×é³É»ò½á¹¹£¬ÓëIGF-1ÓÐÄÇЩ²»Ò»Ñù£¿Ïû·ÑÕßÓÐÖªÇéȨ£¨Éú²ú¹¤ÒÕÄúÃÇ¿ÉÒÔ±£ÃÜ£¬»òÉêÇëרÀû£©¡£ÈôÊÇIGF-1£¬ÕâÊǼ¸Ê®Äêǰ¾Í±»·¢Ïֵĵ°°×ÖÊ£¬ÄúÃÇΪʲôҪÆÛÆ­Ïû·ÑÕߣ¿¶ø¸üÑÏÖØµÄÊÇËüµÄÖ°©×÷Óã¬ÄúÃÇΪʲôֻ×Ö²»Ì᣿µÇÔÚ¡°¿ÆÑ§¡±ÉϵÄÕâÆªÓйØIGF-1Ö°©×÷ÓõÄÎÄÕ£¬ÊÇ1998ÄêµÄÊ£¨4£©£¬ÊǾÅÄêÒÔǰµÄÊ£¬ÕâÑùÖØÒªµÄÎÄÏ×ÄúÃDz»¿ÉÄܲ»¶Á£»¶øÇÒ»¹ÓдóÁ¿¹ØÓÚIGF-1Ö°©×÷ÓõÄÎÄÕ£¬Óм¸ÆªÑо¿¹¤×÷»¹ÊÇÒÔÖйúÈËΪ¶ÔÏó×öµÄ (8, 11)¡£ÄúÃǶÔÕâô¶àÑо¿±¨µÀÈ´ÊÓ¶ø²»¼û£¬ÕâÖ»ÄÜ˵Ã÷ÄúÃÇÓÐÒâºöÓÆÏû·ÑÕß¡£ÄúÃǵĿÆÑ§Á¼ÖªºÎÔÚ£¿ÄúÃÇ×÷ΪÆÕͨÈ˵ÄÁ¼ÐÄÓÖºÎÔÚ£¿ÕâЩÎÊÌâͬÑùÒªÇë½Ì÷·½È¨½ÌÊÚ¡£ÄúÊÇ¡°Ôì¹ÇÅ£Ä̵°°×¡±×¨¼ÒÆÀÉóίԱ»á³ÉÔ±¡¢Öйúũҵ¿ÆÑ§ÔºÎÄÏ×ÐÅÏ¢ÖÐÐÄÖ÷ÈΡ¢Å©Òµ²¿Ç鱨Ñо¿ËùËù³¤¼æ¹ú¼ÒʳÎïÓëÓªÑø×ÉѯίԱ»á³£Îñ¸±Ö÷ÈΡ£Æ¾ÄúµÄѧʶºÍ¹¤×÷Ìõ¼þ£¬Èô¡°Ôì¹ÇÅ£Ä̵°°×¡±¾ÍÊÇIGF-1£¬Äú¶ÔËüÓ¦ÁËÈçÖ¸ÕÆ¡£ÄúΪʲô²»½éÉÜËüµÄÖ÷Òª¹¦ÄÜ£¨Ó°Ïìϸ°ûµÄÔöÖ³£¬·Ö»¯ºÍµòÍö¹ý³Ì£©ºÍÁîÈËÐÄó@µÄÖ°©×÷Ó㬶ø½ö½ö½éÉÜËüµÄ¡°ÏÔÖø¸ÄÉÆ¹Ç÷ÀºÏ³É´úл£¬ÔöÇ¿¹ÇÃܶȣ¬´Ù½ø¹ÇÁ¿Ôö¼Ó£¬ÑÓ»º¹Ç÷ÀË¥ÀÏ¡°µÈ´ÎÒª¹¦ÄÜ£¿£¡ÄúÒ²ÊÇÔÚÓÐÒâºöÓÆÏû·ÑÕߣ¿¹úÍâµÄ¿ÆÑ§½çÊÇǧ·½°Ù¼Æ¼õµÍÈËÌåѪҺÖеÄIGF-1ˮƽ£¬ÒÔ¼õÉÙ»¼°©Ö¢µÄΣÏÕ£¨9£¬14£¬ 18£©¡£¶øÄúÃÇÈ´ÔÚÅ£ÄÌÖÐÌí¼Ó´óÁ¿µÄIGF-1£¬ÕæÈÃÈË¡°·ËÒÄËù˼¡±£¡
¡¡¡¡Éú»îÔÚÕâΨÀûÊÇͼ£¬¹Ù³¡¸¯°Ü£¬ÊǷǵߵ¹£¬ÎÞ¹«Æ½ÕýÒå¿É̸£¬ÈËÖδóÓÚ·¨ÖΣ¬Í÷·¨Í÷ÅУ¨ÈçÎ人ºÍÎ÷°²¼¸¼Ò·¨Ôº¶ÔФ£¬·½ºÍ¶¡£¬·½µÈ°¸¼þµÄÅоö£©µÄÄê´ú£¬ÉõÖÁÐí¶àÈË´¦ÓÚ±»¡°±ÆÁ¼Îªæ½¡±µÄ»·¾³ÖУ¬Òª×öµ½¡°½àÉí×Ժá±£¬¡°³öÎÛÄà¶ø²»È¾¡±£¬È··ÇÒ×Ê¡£µ«ÖÁÉÙ¿ÉÒÔ×öµ½²»¡°ÍƲ¨ÖúÀ½¡±£¬²»¡°ÕÐÒ¡¹ýÊС±£¬²»¡°ÒÔ³ÜΪÈÙ¡± °É¡£
¡¡¡¡×îºó£¬»¹ÊÇÒªÇë¶þλ¿ÆÑ§¼ÒºÍÃÉÅ£¹«Ë¾£¬Ã÷ȷ˵Ã÷OMP¾¿¾¹ÊÇÒ»ÖÖÓÉÄúÃÇз¢Ïֵĵ°°×ÖÊ£¿»¹ÊÇIGF-1£¿ÈôÄúÃDz»¼ÓÒÔ³ÎÇ壬һµ©ºÈÁË¡°ÌØÂ×ËÕ¡±Å£ÄÌ£¬¶øÓÖ»¼ÉÏǰÁÐÏÙ°©£¬»òÈéÏÙ°©£¬»ò·Î°©£¬»ò½á³¦Ö±³¦°©£¬Æ¾ÄúÃǵÄвúÆ·Ðû´«ÄÚÈݺʹóÁ¿µÄ¹ú¼Êҽѧ±¨µÀ£¬Ïû·ÑÕß¾ÍÓÐȨÏòÃÉÅ£¹«Ë¾Ë÷Åâ¡£ÈËÃü¹ØÌ죬¿É²»ÊǶùÏ·°¡£¡

[ Last edited by kkmonkey on 2007-8-3 at 13:29 ]
»Ø¸´´ËÂ¥
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

fhang0427

ľ³æ (ÕýʽдÊÖ)

·½ÖÛ×Óblog:http://www.bullog.cn/blogs/fangzhouzi/archives/38828.aspx

²Î¿¼ÎÄÏ×

1.Burrin DG (1997) Is milk-borne insulin-like growth factor-I essential for neonatal development. J. Nutr. 127, 975S-979s
2.Burrin DG et al (1997) Role of milk-borne vs. endogenous insulin-like growth factor I in neonatal growth. J. Anim. Sci. 75 ,2739-2743
3.Collier RJ et al (1991) Factors affecting insulin-like growth factor-I concentration in bovine milk. J. Dairy Sci. 74, 2905-2911
4.Donovan SM and Odle J (1994) Growth factors in milk as mediators of infant development. Annual Rev. Nutr. 14, 147-167
5.Donovan SM et al (1997) Orally administered iodinated recombinant human insulin-like growth factor-I (IGF-1) is poorly absorbed by the neonatal piglet. J. Pediatr. Gastroenterol. Nutr. 24, 174-182
5.FAO/WHO Joint Committee on Food Additives (1998) Summary and conclusions from Fiftieth Meeting, Rome 17-26 February 1998
6.Hankinson SE et al (1998) Circulating concentrations of insulin-like growth factor 1 and risk of breast cancer. The Lancet, 351 (9113), 9 May 1998, 1393-96
7.Kang SH et al (2006) The effects of dairy processes and storage on insulin-like growth factor-I (IGF-I) content in milk and in model IGF-I-fortified dairy products. J Dairy Sci. 2006 89(2):402-9
8.NIH Technology Assessment Conference (1991) Statement on bovine somatotropin. JAMA 265, 1423-1425
9.Odle J et al (1996) Intestinal effects of milk borne growth factors in neonates of agricultural importance. J. Anim. Sci. 74, 2509-2522
10.Renehan AG et al (2004) Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363, 1346¨C1353
.......
2Â¥2007-05-28 23:27:50
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

zdliu

ÖÁ×ðľ³æ (СÓÐÃûÆø)

Ì«¿ÉÅÂÁË,Òª³öÈËÃüÁË.ÒÔºóÔÚÒ²²»ÄÜÂòÌØÂ×ËÕÁË
3Â¥2007-05-28 23:36:53
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

xzbb

Í­³æ (СÓÐÃûÆø)

Ìý˵¹âÃ÷µÄÓżÓÊÇͬһµµ´ÎµÄ²úÆ·¡£ÒÔºóºÈÓżÓÁË¡£
4Â¥2007-05-28 23:38:37
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

chenchenand

гæ (СÓÐÃûÆø)

9494,Ò»Ö±²»Ï²»¶ÃÉÅ££¬Õâϸü²»ÄÜÒûÓÃÁË£¬´ó¼ÒҲҪСÐÄ
5Â¥2007-05-28 23:47:15
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

liukelly

½ð³æ (СÓÐÃûÆø)

ûºÈ¹ý£¬ÒÔºóÒ²²»¸ÒºÈÁË
6Â¥2007-05-28 23:51:09
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

royalgala

Í­³æ (³õÈëÎÄ̳)

ÃÉÅ£,ÒÁÁ¦µÄÒ»Ö±Êǃžì¶ÆäËûÆ·ÅÆ,

 IðBŒWÀÏŽŸ·ÖÎöËûµÄ³É·ÝÒ²ÊÇÕýÃæÔuƒr£¨Ò»°ãÅ£ÄÌ£©

Œ¦ì¶ÌØ?öÌKß@‚€®aÆ·µÄ³É·Ý,ÃÉÅ£‘ªÔ“³ö?í½âáŒÒ»ÏÂ
7Â¥2007-05-29 01:22:16
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

shuangwaiwai

½ð³æ (СÓÐÃûÆø)

ÅóÓÑ£¬ ÄúÌ«ÓвÅÁË£¡ ¶ÔÕâЩÃÁ×ÅÁ¼ÐÄ׬ºÚÐÄÇ®µÄ³§ÉÌ£¬ÕâЩΨÀû¡¢Î¨ÃûÊÇͼµÄѧÊõ¸¯°Ü·Ö×ÓµÄÈ·Ó¦¸ÃÀ­³öÀ´Ê¾ÖÚ°¡£¡»½ÆðÃñÖÚ£¡
8Â¥2007-05-29 09:21:01
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

fhang0427

ľ³æ (ÕýʽдÊÖ)

ÔõôûÓÐÈ˶¥°¡
9Â¥2007-05-29 14:05:17
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

hjma65

½ð³æ (ÕýʽдÊÖ)

ding!»¹ÓÐÆäËüÀàËÆµÄÇé¿öÂð£¿ÆäËüÅÆ×ÓµÄÅ£ÄÌÈçºÎ£¿
10Â¥2007-05-29 16:27:19
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ fhang0427 µÄÖ÷Ìâ¸üÐÂ
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û