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leaoman

银虫 (小有名气)

[求助] 请教辛伐他汀BCS分类

请教各位,有没有知道辛伐他汀  BCS分类的,要有具体出处,谢谢了。
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caohouping

木虫 (正式写手)

【答案】应助回帖

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感谢参与,应助指数 +1
leaoman: 金币+49, ★★★★★最佳答案 2012-08-23 15:28:05
Biopharmaceutics Classification System (BCS) Results


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Records found: 1 Compound: Simvastatin
  
CAS: 79902-63-9
Category: Cardiovascular Agents
Subcategory: HMG-CoA Reductase Inhibitors
Formula: C25 H38 O5
Molecular Weight: 418.559997559
Lowest Solubility (mg/ml): 0.00999999977648  
Human Permeability (x 10^4 cm/s): N/A  
cLogP: 4.48099994659  HIGH Permeability   
logP: 4.38999986649  HIGH Permeability   
Country List: Minimum Dose (mg) Maximum Dose (mg) Do (min) Do (max) Solubility BCS Class (cLogP) BCS Class (logP)
JP 5 20 3.33333349228 13.3333339691 LOW  Class II  Class II  
KOR 20 40 8 16 LOW  Class II  Class II  
SP 5 40 2 16 LOW  Class II  Class II  
UK 5 80 2 32 LOW  Class II  Class II  
US 5 80 2 32 LOW  Class II  Class II  






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http://69.20.123.154/services/bcs/results.cfm
3楼2012-08-22 08:28:41
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yl0602

铜虫 (初入文坛)

【答案】应助回帖

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感谢参与,应助指数 +1
zhychen2008: 金币+1, 感谢回帖交流 2012-08-21 23:54:52
leaoman: 金币+1 2012-08-23 15:28:10
Simvastatin is classified as BCS II drug which has been stated in many publications.
2楼2012-08-21 20:56:57
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