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johnzhl01铁杆木虫 (著名写手)
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书名 Practice of Medicinal Chemistry, 2nd ed ISBN-10 0-12-744481-5 作者 C. Wermuth, ed. 出版社 Academic Press, 2003, 624 pp., hard cover 目录 A Brief History Of Drugs; From Plant Extracts To DNA Technology. Medicinal Chemistry: Definition And Objectives, The Three Main Phases Of Drug Activity, Drug And Diseases Classifications. Measurement And Expression Of Drug Effects. Drug Targets: Molecular Mechanisms Of Drug Action. Strategies In The Search For New Lead Compounds Or Original Working Hypotheses. Natural Products As Pharmaceuticals And Sources For Lead Structures. Basics Of Combinatorial Chemistry. The Contribution Of Molecular Biology To Drug Discovery. Electronic Screening: Lead Finding From Database Mining. High-Speed Chemistry Libraries: Assessment Of Drug-Likeness. Web Alert - Using The Internet For Medicinal Chemistry. Molecular Variations In Homologous Series: Vinylogues And Benzologues. Molecular Variations Based On Isosteric Replacements. Ring Transformations. Introduction Of Conformational Restriction And/Or Steric Hindrance. Identical And Non Identical Twin Drugs. Optical Isomerism In Drugs. Application Strategies For The Primary Structure-Activity Relationship Exploration. Specific Substituent Groups. The Role Of Functional Groups In Drug–Receptor Interactions. Compound Properties And Drug Quality. Quantitative Approaches To Structure-Activity Relationships. Structural Aspects Of Drug Action I. Pharmacophore Identification And Receptor Mapping. Three-Dimentional Quantitative Structure-Property Relationships. Protein Crystallography And Drug Discovery. Protein Comparative Modelling And Drug Discovery. The Transition From Agonist To Antagonist Activity: Symmetry And Other Considerations. Design Of Peptidomimetics. The Fate Of Xenobiotics In Living Organisms. Biotransformation Reactions. Chemical Mechanisms Of Toxicity. Basic Knowledge For Designing Safer Drugs. Designing Prodrugs And Bioprecursors. Macromolecular Carriers For Drug Targeting. Preparation Of Water Soluble Compounds Through Salt Formation. Preparation Of Water-Soluble Compounds By Covalent Attachment Of Solubilizing Moieties. Drug Solubilization With Organic Solvents, Surfactants And Lipids. Improvement Of Drug Properties By Cyclodextrins. Chemical And Physicochemical Solutions To Formulation Problems. Discover A Drug Substance, Formulate And Develop It To A Product. Drug Nomenclature. Legal Aspects Of Product Protection. The Consumption And Production Of Pharmaceuticals. 下载链接： http://a.thec.cn/fwangj/practice_of_medicinal_chemistry.pdf [ Last edited by johnzhl01 on 2007-5-19 at 18:16 ] |
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