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A post-doctoral research position is available from 1 September 2012 in the research group of Dr. Robert Best at the University of Cambridge. The project will focus on the development of a ligand diffusion-reaction model in enzymes by combining methods from computational chemistry and biophysics. The method will be applied to [FeFe]-hydrogenase, a promising biocatalyst for future production of biohydrogen. The theoretical simulations will support and guide ongoing bioengineering efforts aimed at making the enzyme more robust against inhibition and oxidative damage. These are some of the main obstacles that hamper the use of hydrogenases on an industrial scale. The project will be carried out in collaboration with experimentalists in France and with Dr. Jochen Blumberger at University College London. Access to high performance computing facilities will be provided.

The ideal candidate should have or be about to obtain a PhD in theoretical/physical chemistry or physics. Experience in classical simulation methodology, master equation models, biased sampling methods and shell scripting (preferably python/Matlab) is required.

Applications should include a CV, publications list, contact details for three professional referees, and a completed form CHRIS/6 Parts I and III (downloadable from http://www.admin.cam.ac.uk/offices/hr/forms/chris6/), and should be sent to Dr Robert Best, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW (email: rbb24@cam.ac.uk).

The funds for this post are available for two years in the first instance.
Quote Reference: MA18502,Closing Date: 6 August 2012
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