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yufu0522木虫 (正式写手)
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[求助]
求英文摘要翻译（生物方面的）！
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| Addition of the amino acids threonine,serine,proline,and arginine to fermentations of the fungus Glarea lozoyensis influenced both the pneumocandin titer and the spectrum of analogues produced. Addition of threonine or serine altered the levels of the “serine analogues” of pneumocandin B0 and B5 and allowed for their isolation and identification. Proline supplementation resulted in a dose-dependent increase in the levels of pneumocandin B0 and E0, whereas pneumocandin C0 and D0 decreased as a function of proline level. Moreover, proline supplementation resulted in an overall increase in the synthesis of both trans-3- and trans-4-hydroxyproline while maintaining a low trans-4-hydroxyproline to trans-3-hydroxyproline ratio compared to the unsupplemented culture. pneumocandin production and the sythesis of hydroxyprolines was also affected by addition of the proline-related amino acid arginine but not by the addition of glutamine or ornithine.Zinc,cobalt,copper,and nickel,trace elements that are known to inhibit α-ketoglutarate-dependent dioxygenases, affected the pneumocandin B0 titer and altered the levels of pneumocandins B1, B2，B5，B6，and E0，analogues that possess altered proline,ornithine,and tyrosine hydroxylation patterns. |
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2楼2012-07-17 10:35:27
yufu0522
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3楼2012-07-17 21:52:02
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4楼2012-07-17 22:07:39
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Addition of the amino acids threonine,serine,proline,and arginine to fermentations of the fungus Glarea lozoyensis influenced both the pneumocandin titer and the spectrum of analogues produced. 在真菌Glarea lozoyensis（菌种，专业名词）中添加苏氨酸、丝氨酸、脯氨酸和精氨酸会影响pneumocandin（专业名词，是卡泊芬净前体）滴度和产生的类似物光谱。 Addition of threonine or serine altered the levels of the “serine analogues” of pneumocandin B0 and B5 and allowed for their isolation and identification. 添加苏氨酸和丝氨酸改变pneumocandinB0和B5的“丝氨酸类似物”的水平并影响分离和鉴别。 Proline supplementation resulted in a dose-dependent increase in the levels of pneumocandin B0 and E0, whereas pneumocandin C0 and D0 decreased as a function of proline level. 添加补充脯氨酸导致pneumocandinB0和E0水平随脯氨酸剂量增加而增加，然而pneumocandinC0和D0降低。 Moreover, proline supplementation resulted in an overall increase in the synthesis of both trans-3- and trans-4-hydroxyproline while maintaining a low trans-4-hydroxyproline to trans-3-hydroxyproline ratio compared to the unsupplemented culture. 除此之外，脯氨酸添加导致反式3和反式4羟基脯氨酸合成整体增加，然而却和未添加脯氨酸培养相比，添加脯氨酸的反-4、反-3 羟基脯氨酸却维持在低水平。 pneumocandin production and the sythesis of hydroxyprolines was also affected by addition of the proline-related amino acid arginine but not by the addition of glutamine or ornithine. 脯氨酸相关氨基酸精氨酸同样会影响pneumocandin的产物及羟基脯氨酸的合成，而谷氨酸盐和鸟氨酸则不会。 Zinc,cobalt,copper,and nickel,trace elements that are known to inhibit α-ketoglutarate-dependent dioxygenases, affected the pneumocandin B0 titer and altered the levels of pneumocandins B1, B2，B5，B6，and E0，analogues that possess altered proline,ornithine,and tyrosine hydroxylation patterns. 已知锌、钴、铜和锡，痕量元素会抑制α-酮戊二酸依赖性的加双氧酶，影响 pneumocandin B0滴度，改变 pneumocandin B1，B2，B5，B6和E0，拥有改变脯氨酸、鸟氨酸酪氨酸羟基化模式的类似物的含量。 专业名词我没有翻译，毕竟不是这个领域的。看到一篇中文文献，楼主自己参考把。 https://www.cnki.com.cn/Article/CJFDTotal-HBHG201109026.htm 希望都楼主有用。 |
5楼2012-07-18 09:46:34
