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mengdragon木虫 (著名写手)
muchong
|
[求助]
请教一下各位搞制剂或药代的同仁 为什么大豆油和蓖麻油可以用来注射呢
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| 请教一下各位搞制剂或药代的同仁 为什么大豆油和蓖麻油可以用来做注射制剂的辅料呢 这个东东到了血液里怎么整啊 |
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【答案】应助回帖
★ ★ ★ ★
感谢参与，应助指数 +1
豆哥: 金币+1, 谢谢参与交流 2012-07-03 11:36:26
mengdragon: 金币+3, ★★★★★最佳答案, 非常感谢@！！！！ 2012-07-10 14:33:23
感谢参与，应助指数 +1
豆哥: 金币+1, 谢谢参与交流 2012-07-03 11:36:26
mengdragon: 金币+3, ★★★★★最佳答案, 非常感谢@！！！！ 2012-07-10 14:33:23
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Soybean oil is widely used intramuscularly as a drug vehicle or as a component of emulsions used in parenteral nutrition regimens; it is also consumed as an edible oil. Generally, soybean oil is regarded as an essentially nontoxic and nonirritant material. However, serious adverse reactions to soybean oil emulsions administered parenterally have been reported. These include cases of hypersensitivity,(37) CNS reactions,(38) and fat embolism.(39) Interference with the anticoagulant effect of warfarin has also been reported.(40) Anaphylactic reactions have also been reported following the consumption of foods derived from, or containing, soybeans. Recently there has been concern at the concentration of phytoestrogens in some soy-derived products. Administration of soy protein to humans has resulted in significantly decreased serum lipid concentrations.(41) In 1999, the UK Medical Devices Agency announced the voluntary withdrawal of a breast implant that contained soybean oil. The decision was taken because not enough was known at that time about the long-term safety and the rate of breakdown of the soybean oil in the filling and its possible effects on the body.(42) LD50 (mouse, IV): 22.1 g/kg(43) LD50 (rat, IV): 16.5 g/kg 以上摘自《药用辅料手册》，豆油、蓖麻油作为注射用油还是有一定毒副作用的！因此有用结构中链油来代替豆油的。 这也是载药乳剂不如脂质体、纳米粒等给药系统更为人接受的原因吧？？？  |
2楼2012-07-03 10:46:01
3楼2012-07-03 11:57:58
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