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(?) ??????????????????е???????????? ???? ???????????????????-1??IGF-1?????????????? ?????????Renzhuli ????????⿴??????????????·???????????????????????????????????????????磬??????Ц????????????????磬?????????????????е??????????????????????????????????????е????????????????????Щ??????????????????????????????棬???????壬???????????????????廨???????о??У?????Ψ??????????????????????????????÷з??????????????????????????е???????????? ??OMP??????????????о???????й???????????м?????????????????????????й????????????????????????????????????????????????????·??????????????????????????????????????????????????????????????????????????????????????????????????????·?????????????ǹ???????????????????????????-1??IGF-1?????????????????????????????????÷???????????????????????????У??????????ɡ?????????70???????????????7649?????????????????????????????-1?????????????????????????????????????????????????????- 1??????????????????塱?????????????С??С?????????????????о??У?????????????????? ???? ????????????????????е??????????ù??????????????????????xx??????δ?????????????κγ???????????????????????????????????????????????????????????-1???????????????????????????????????????-1??IGF-1????????????????????IGF-1???????????????????????1??2??17???????????????3??18?????????????????? (4-8)????? (10-13)????????(14-16)???????????????????????19????????????????????????????????????????????????????????????????????IGF-1??????????????????????????????????????ν????????á??????????????????????????????????IGF-1????????????????????????????????????????????????????????飬???е?????????????????????????????????????????????????????????????????????????????о??????????????????????????????????????????????????????????????????????????????????????IGF-1????θ?????б???????????????????????????????У??????????????????????????????????????????????ν??????????????????????Щ?????????ЩС????Σ??????????????????????????????????????????????????岻???к????????棬????????????????????????? ???? д??????????????????????????????????????????????OMP???????????????????????????????????????????·????????????????????????????????????????IGF-1????Щ?????????????????????????????????????????????????????????IGF-1???????????????????????????????????????????????????????????°????????????????????????????????????й?IGF-1?°?????????????1998??????4??????????????????????????????????????????????????д???????IGF-1?°????????????м???о????????????й???????????? (8, 11)?????????????о?????????????????????????????????????????????????????????????????????????????????Щ???????????÷???????????????????????????????????????й?????????????????????Ρ??????鱨?о????????????????????????????????Ρ?????????????????????????????????????IGF-1???????????????????????????????????????????????????????????????????????????@???°????????????????????????????????????л?????????????????????????????????????????????????????????????????????????????????????????????е?IGF-1???????????????Σ???9??14?? 18???????????????????????????IGF-1???????????????????? ???? ????????Ψ?????????????????????????????????????δ?????Σ????????У????人??????????????Ф???????????????????о???????????????????????????????潡???????У??????????????á?????????????????????????????????????????????????????????????????С?????????????? ?ɡ? ???? ??????????λ????????????????????OMP????????????????·??????????????IGF-1???????????????壬??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? 1?? Khandwala HM et al. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr. Rev. 21:215-44. 2000. 2?? Jerome L. et al. Deregulation of the IGF axis in cancer: epidemiol. Evidence and potential therapeutic intervention. Endocr. Relat. Cancer. 10:561-78. 2003. 3?? Yu H. et al. Joint effect of insulin-like growth factors and sex steroids on breast cancer risk. Cancer Epidemiol. Biomarkers and Prev. 12:1067-73.2003. 4?? Chan JM, Stampfer MJ, Giovannucci E. et al. Plasma insulin-like growth factor-1 and prostate cancer risk: A prospective study. Science 279:563-6. 1998. 5?? Chan JM, Stampfer MJ, et al. Insulin-like growth factor-1 and Insulin-like growth factor binding protein-3 as predicators of advanced-stage prostate cancer. J. Natl. Cancer Inst. 94:1099-1106. 2002 6?? Shi R., Berkel HJ, Yu H. Insulin-like growth factor-1 and prostate cancer: a meta-analysis. Br. J. Cancer. 85:991-6. 2001. 7?? Oliver SE et al. Screen-detected prostate cancer and the Insulin-like growth factor axis: results of a population-based case-control study. Int. J. Cancer 108:887-92. 2004. 8?? Chokkalingam AP et al. Insulin-like growth factors and prostate Cancer: a population-based case-control study in China. Cancer Epidemiol. Biomarkers and Prev. 10:421-7. 2001. 9?? Voskuil DW et al. The insulin-like growth factor system in cancer prevention: potential of dietary intervention strategies. Cancer Epidemiol. Biomarkers and Prev. 14 (1):195-203. 2005 Jan 10?? Yu H. et al. Plasma levels of insulin-like growth factor-1, IGF-binding protein-3 and lung cancer risk: a case-control analysis. J. Natl. Cancer Inst. 91:151-6. 1999. 11?? London SJ. Et al. Insulin-like growth factor-1, IGF-binding protein-3 and lung cancer risk in a prospective study of men in China. J. Natl. Cancer Inst. 94:749-54. 2002. 12?? Lee HY. Et al. Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. Cancer Res. 62:5530-7. 2002. 13) Liu C. et al. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein-3 in cigarette smoke ferrets. Cancer Res. 63-3138-44. 2003. 14) Vrieling A. et al. Isolated isoflavones do not affect the circulation Insulin-like growth factor system in man at increased colorectal cancer risk. J. Nutr. 137 (2):379-83. 2007 Feb 15) Giovannucci E. et al. A prospective study of plasma Insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. Cancer Epidemiol Biomarkers and Prev. 9:345-9. 2000. 16??Giovannucci E Insulin-like growth factors and colon cancer: a review of the evidence. J. Nutr. 131:3109s-20s. 2001 17?? Renchan AG. et al. Insulin-like growth factor (IGF)-1, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet. 363:1346-53. 1994. 18?? Furstenberger G. et al. Serum levels of IGF-1 and IGFBP-3 during adjuvant chemotherapy for primary breast cancer. Breast 15(1):64-68, 2006 Feb. 19?? Zhao H. et al. Plasma levels of insulin-like growth factor-1 and binding protein-3, and their association with bladder cancer risk. J. Urology 169(2):714-7, 2003 Feb. |
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