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| As will be explained in detail in the following a wheat bran extract, or an isolate from the extract, is found to inhibit the production of ¦Â-hexosaminidase in the IgE-primed RBL-2H3 (rat basophilic leukemia) mast cells stimulated with the antigen DNP-BSA. Expressing a high level of the IgE receptor (Fc¦ÅRI) on the surface thereof, the mast cell line RBL-2H3 is known to release allergic mediators upon degranulation by IgE and an antibody. ¦Â-hexosaminidase is known as a marker of the degranulation |
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