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1121prettycat木虫 (正式写手)
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[求助]
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| 影响化合物在机体中分布的因素很多，主要有药物的脂溶性、毛细血管通透性、器官和组织的血流量、与血浆蛋白和组织蛋白的结合率等。暴露期结束时，肺脏中AHTN含量最高，尤其是中、高剂量的AHTN暴露后，肺脏中AHTN的含量远远高于其它组织，表明肺脏是AHTN在体内的主要蓄积器官。至于AHTN为什么会在肺中有较高分布，是否是由于肺脏中的血流量大、AHTN能否与肺细胞表面的某些特异性受体结合以及会带来哪些影响，还需要作进一步的研究。肝脏和肾脏中有较高的AHTN分布，提示AHTN有可能通过肾脏和肝脏的排泄作用而被清除出体外。心脏中检测到较高浓度的AHTN，主要是由于心脏的血流量大的缘故。脑组织中AHTN的含量高于血液中AHTN的含量，表明AHTN能穿过血脑屏障，进而在脑组织中蓄积，这可能是因为AHTN的分子量相对较小，脂溶性高引起的。此外，尽管睾丸的血流量要低于其它组织，但是由于睾丸中脂肪含量相对较高，其对脂溶性较强的AHTN也有一定的蓄积能力。 |
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jeangong
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爱与雨下: 金币+2 2012-06-10 19:19:41
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爱与雨下: 金币+2 2012-06-10 19:19:41
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There are many factors that affect the compounds in the distribution in the body, such as lipid-soluble of drugs, capillary permeability, blood flow to organs and tissues, and plasma protein and tissue protein binding rate and so on. There are the highest AHTN content in the Lung afer exposure period, especially after exposure to medium and high doses of AHTN, the content of the lungs AHTN is much higher than other organizations, whichi showed that the lung is the main accumulation AHTN organs of the body. Why AHTN in the lungs have a higher distribution, whether it is due to the blood volume in the lungs, or the AHTN whether the surface of the lung cells of certain specific receptor binding and what impact, these need the further research. Liver and kidney have a higher the AHTN distribution, which suggested that the the AHTN there may excretion through the kidneys and liver were removed from the in vitro. Detected the higher concentrations of AHTN in the heart, which mainly caused due to the big blood flow volume of the heart's. The content of AHTN in brain tissue is higher than those of in the blood, showed that AHTN can through the blood-brain barrier, and thus accumulate in the brain, which may be caused because of the AHTN's relatively small molecular weight, fat-soluble high. In addition, although the testicular blood flow is lower than other organizations, but the fat content is relatively high due to the testis, and its accumulation on the fat-soluble strong AHTN. |
2楼2012-06-10 15:14:25
sesame_oil
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book2005593: 金币-7, google在线翻译，收回奖励并按规定扣5金币！ 2012-06-11 15:41:47
book2005593: 违规存档, 违规用goole在线翻译~ 2012-06-11 15:45:13
爱与雨下: 金币+2 2012-06-10 19:19:51
book2005593: 金币-7, google在线翻译，收回奖励并按规定扣5金币！ 2012-06-11 15:41:47
book2005593: 违规存档, 违规用goole在线翻译~ 2012-06-11 15:45:13
| There are many factors affect the compounds in the distribution in the body, mainly the fat-soluble drugs, capillary permeability, blood flow to organs and tissues, and plasma protein and tissue protein binding rate and so on. The end of the exposure period, AHTN content in the lungs of the highest, especially after exposure to high doses of AHTN, the content of the lungs AHTN is much higher than other organizations, suggesting that lung AHTN main accumulation organ in the body.Why As for AHTN in the lungs have a higher distribution, whether it is due to the blood volume in the lungs, the AHTN whether the surface of the lung cells of certain specific receptor binding and what impact, the need for further research.Liver and kidney have a higher the AHTN distribution, suggesting that the the AHTN there may excretion through the kidneys and liver were removed from the in vitro.Detected in higher concentrations of AHTN in the heart, mainly due to the blood flow volume of the heart's sake.AHTN the content is higher than the content of AHTN blood in brain tissue, showed that AHTN through the blood-brain barrier, and thus accumulate in the brain, which may be because it the AHTN's relatively small molecular weight, fat-soluble high caused.In addition, although the testicular blood flow is lower than other organizations, but the fat content is relatively high due to the testis, and its accumulation on the fat-soluble strong AHTN. |
3楼2012-06-10 15:38:19
1121prettycat
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4楼2012-06-10 23:23:10
book2005593
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5楼2012-06-11 15:38:36