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LFJ0319

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Indeed, ferrocene derivatives have been proposed as antianemics, and one such compound, ferrocerone, was
clinically approved in the USSR. To the best of our knowledge, this compoundwas the firstmarketed transition organometal drug. In this context, it is worth mentioning that another ferrocene-containing compound, which is a close
derivative of chloroquine, has successfully passed clinical phase II trials as an antimalarial drug candidate

The idea of using ruthenium-containing organometallics as anticancer agents was first developed by Tochter et al.

[ Last edited by LFJ0319 on 2012-5-28 at 22:49 ]

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sltmac: 金币+1 2012-05-31 08:51:15
sltmac: 金币+5, 翻译EPI+1 2012-06-20 09:28:49

Indeed, ferrocene derivatives have been proposed as antianemics, and one such compound, ferrocerone, was clinically approved in the USSR. 确实，二茂铁衍生物已被推荐为抗贫血药，其中一个化合物已在USSR获得临床许可。To the best of our knowledge, this compoundwas the firstmarketed transition organometal drug. 就我们所知，此化合物是第一个市场化的有机金属药物。In this context, it is worth mentioning that another ferrocene-containing compound, which is a close derivative of chloroquine, has successfully passed clinical phase II trials as an antimalarial drug candidate在这种背景下，值得一提的是，另一个含二茂铁的化合物，是氯喹的亲缘衍生物，已经成功地通过了抗疟候选药物二期临床。The idea of using ruthenium-containing organometallics as anticancer agents was first developed by Tochter et al.采用含钌有机金属化合物为抗肿瘤药物的思想最早由Tochter等提出。