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一篇有关聚合物纳米粒在药物，基因传递方面的综述和展望
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综述 ：Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery Abstract Polymeric micelles, self-assemblies of block copolymers, are promising nanocarrier systems for drug and gene delivery. Until now, several micellar formulations of antitumor drugs have been intensively studied in preclinical and clinical trials, and their utility has been demonstrated. Even compared with long-circulating liposomes, polymeric micelles might have several advantages, such as controlled drug release, tissuepenetrating ability and reduced toxicity such as hand–foot syndrome and hypersensitivity reaction. Importantly, critical features of the polymeric micelles as drug carriers, including particle size, stability, and loading capacity and release kinetics of drugs, can be modulated by the structures and physicochemical properties of the constituent block copolymers. Also, nano-engineering of block copolymers might allow the preparation of polymeric micelles with integrated smart functions, such as specific-tissue targetability, as well as chemical or physical stimuli-sensitivity. Thus, polymeric micelles are nanotechnology-based carrier systems that might exert the activity of potent bioactive compounds in a site-directed manner, ensuring their effectiveness and safety in the clinical use. © 2006 Elsevier Inc. All rights reserved. 当您的朋友需要提取此文件时只需: 匿名提取文件连接 http://pickup.mofile.com/2942934516619212 或登录Mofile，使用提取码 2942934516619212 提取文件 [search]纳米 给药[/search] [ Last edited by euroho on 2007-4-17 at 16:47 ] |
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