| 查看: 2170 | 回复: 5 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
makuna木虫 (正式写手)
|
[交流]
PhD position Germany 已有4人参与
|
||
|
Heparan sulfate proteoglycans (HSPGs) are expressed on all cells of developing and adult vertebrate and invertebrate organisms. Their Heparan sulfate (HS) sugar chains play important roles in growth and differentiation, cell migration and survival by binding to a vast number of growth factors and morphogens. One such HS-binding morphogen/growth factor is Sonic hedgehog (Shh). Due to their important roles in development and cancer, the mechanisms of HS-regulated Shh release and spreading to responding cells are of great interest. We recently found that Shh is released from the producing cells by ADAM (A Disintegrin And Metalloprotease) mediated shedding. Based on this release mechanism, we plan to investigate the following: - How is Shh release from producing cells regulated? - Shh is released in clustered form. Are these clusters homo-or heteromultimers? What is their structure? How is their size regulated? - How do these clusters spread through the extracellular matrix? The applicant will hold a Masters degree and has gained first biochemical research experience. Experience in Drosophila experimentation is highly welcome, but not required. The successful applicant will find strong support within the excellent interdisciplinary environment of the first Indo-German Research and Training group in Molecular and Cellular Glyco-Sciences (MCGS). Methoden: A wide range of biochemical methods will be employed, such as recombinant mutant protein production and chromatographic/functional characterization, determination of Shh/HS binding (Biacore), and in vivo testing of any obtained models of protein release and clustering. Anfangsdatum: 1. September 2012 geschätzte Dauer: 3 Jahre Bezahlung: ?1,400 per month, tax-free Veröffentlichungen: please refer to http://physiolchem.uni-muenster.de/forschen/gro_papers.html Homepage: http://physiolchem.uni-muenster.de/forschen/gro_index.html please also refer to http://www.uni-muenster.de/MCGS/ [ Last edited by flyingskynk on 2012-5-18 at 19:00 ] |
回复此楼» 猜你喜欢
垃圾破二本职称评审标准
已经有19人回复
-
职称评审没过，求安慰
已经有53人回复
-
毕业后当辅导员了，天天各种学生超烦
已经有5人回复
-
26申博自荐
已经有3人回复
-
A期刊撤稿
已经有4人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 亥姆霍兹慕尼黑中心/慕尼黑工大Wurst教授物色神经发育分子学公派博士生
已经有13人回复
- 请问PhD/research assistant position与PhD position的区别？
已经有6人回复
- KIT 环境与气象研究所招全球气候变化对生物环境影响方向的博士生两名
已经有17人回复
- 【招聘】PhD Position in Universit?t Paderborn Germany
已经有6人回复
- 【资源】被遗忘的德国亥姆霍兹联合会对中国CSC奖学金申请人的开放40余个博士生、博士�
已经有51人回复
- 【资源】PhD position at Monash University
已经有13人回复
- 【分享】蛋白质结构预测流程
已经有32人回复
- 【版内活动】晒出你的OFFER，分享你的喜悦
已经有71人回复
- 两个Offer如何选择和拒绝掉另外一个
已经有25人回复
makuna
木虫 (正式写手)
- 点评EPI: 2
- 应助: 4 (幼儿园)
- 金币: 1550.2
- 散金: 50
- 红花: 8
- 帖子: 377
- 在线: 190.8小时
- 虫号: 302541
- 注册: 2006-12-02
- 性别: GG
- 专业: 应用高分子化学与物理
6楼2012-08-07 10:02:22
小路-road
木虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 2775.8
- 散金: 30
- 红花: 2
- 帖子: 171
- 在线: 234.8小时
- 虫号: 863514
- 注册: 2009-10-05
- 专业: 无机纳米化学
2楼2012-05-16 10:52:00
henghai
木虫 (正式写手)
- 应助: 8 (幼儿园)
- 金币: 1926.8
- 散金: 453
- 红花: 2
- 帖子: 495
- 在线: 314.8小时
- 虫号: 486446
- 注册: 2007-12-27
- 性别: GG
- 专业: 电化学
3楼2012-05-16 18:41:26
4楼2012-05-17 00:21:20