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[求助]
求医学生 翻译某论文里的一段话
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Sample TextThe nuclear receptor retinoid X receptor (RXR) functions potently in the regulation of homeostasis and cell development, while rexinoids as RXR agonists have proved their therapeutic potential in the treatment of metabolic diseases and cancer. Here, the natural product bigelovin was identified as a selective RXRα agonist. Interestingly, this compound could not transactivate RXRα:RXRα homodimer but could enhance the transactivation of RXRα:peroxisome proliferator-activated receptor γ heterodimer and repress that of RXRα:liver X receptor (LXR) α heterodimer, while it had no effects on RXRα:farnesoid X receptor heterodimer. Considering that the effective role of LXR response element involved transactivation of sterol regulatory element-binding protein-1c mediated by RXRα:LXRα in triglyceride elevation, such LXR response element repressing by bigelovin has obviously addressed its potency for further research. Moreover, our determined crystal structure of the bigelovin-activated RXRα ligandbinding domain with the coactivator human steroid receptor coactivator-1 peptide revealed that bigelovin adopted a distinct binding mode. Compared with the known RXR ligands, bigelovin lacks the acidic moiety in structure, which indicated that the acidic moiety rendered little effects on RXR activation. Our results have thereby provided new insights into the structure-based selective rexinoids design with bigelovin as a potential lead compound. |
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8814402
至尊木虫 (职业作家)
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2楼2012-05-15 09:41:32
8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
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★ ★ ★
爱与雨下: 金币+1 2012-05-15 20:22:31
jyf2010: 金币+2, 翻译EPI+1, ★有帮助 2012-05-20 16:14:05
爱与雨下: 金币+1 2012-05-15 20:22:31
jyf2010: 金币+2, 翻译EPI+1, ★有帮助 2012-05-20 16:14:05
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The nuclear receptor retinoid X receptor (RXR) functions potently in the regulation of homeostasis and cell development, while rexinoids as RXR agonists have proved their therapeutic potential in the treatment of metabolic diseases and cancer.核受体视黄醇类X受体（RXR)具有调控内稳态和细胞发育的功能，而rexinoids 作为RXR激动剂已经证实具有代谢性疾病和癌症的治疗潜力。 起个头，有个词似乎还没有明确的汉语对应，研究者可能都知道吧 |
3楼2012-05-15 10:05:29
4楼2012-05-20 16:13:33
8814402
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5楼2012-05-21 07:47:18
6楼2012-05-21 14:39:34
8814402
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7楼2012-05-21 15:32:44
8楼2012-05-22 15:27:20
8814402
至尊木虫 (职业作家)
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我服了你了，MM，你是懒，而不是苯！ Interestingly, this compound could not transactivate RXRα:RXRα homodimer but could enhance the transactivation of RXRα:peroxisome proliferator-activated receptor γ heterodimer and repress that of RXRα:liver X receptor (LXR) α heterodimer, while it had no effects on RXRα:farnesoid X receptor heterodimer. Considering that the effective role of LXR response element involved transactivation of sterol regulatory element-binding protein-1c mediated by RXRα:LXRα in triglyceride elevation, such LXR response element repressing by bigelovin has obviously addressed its potency for further research. Moreover, our determined crystal structure of the bigelovin-activated RXRα ligandbinding domain with the coactivator human steroid receptor coactivator-1 peptide revealed that bigelovin adopted a distinct binding mode. Compared with the known RXR ligands, bigelovin lacks the acidic moiety in structure, which indicated that the acidic moiety rendered little effects on RXR activation. Our results have thereby provided new insights into the structure-based selective rexinoids design with bigelovin as a potential lead compound. |
9楼2012-05-22 16:48:12
8814402
至尊木虫 (职业作家)
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★ ★ ★ ★ ★ ★ ★ ★
jyf2010: 金币+8 2012-05-27 21:52:29
jyf2010: 金币+8 2012-05-27 21:52:29
| Interestingly, this compound could not transactivate RXRα:RXRα homodimer but could enhance the transactivation of RXRα:peroxisome proliferator-activated receptor γ heterodimer and repress that of RXRα:liver X receptor (LXR) α heterodimer, while it had no effects on RXRα:farnesoid X receptor heterodimer. 有趣的是，这一化合物不能超激活xx同源二聚体，但能够加强xx异质二聚体的超激活并抑制xx异质二聚体的反式活化，而对xx异质二聚体没有作用。Considering that the effective role of LXR response element involved transactivation of sterol regulatory element-binding protein-1c mediated by RXRα:LXRα in triglyceride elevation, such LXR response element repressing by bigelovin has obviously addressed its potency for further research. 考虑到由xx介导与LXR响应元件有关的固醇调控元件结合蛋白的超激活在甘油三酯升高中的有效作用，与锦菊素对LXR响应元件的抑制显然引起了对其效能的研究兴趣。Moreover, our determined crystal structure of the bigelovin-activated RXRα ligandbinding domain with the coactivator human steroid receptor coactivator-1 peptide revealed that bigelovin adopted a distinct binding mode. 此外，我们所确定的xx的晶体结构也提示与锦菊素以一种截然不同的方式 与xx结合。Compared with the known RXR ligands, bigelovin lacks the acidic moiety in structure, which indicated that the acidic moiety rendered little effects on RXR activation.与众所周知的RXR配体相比，与锦菊素缺乏酸性结构，提示酸性结构对RXR的激活作用有限。 Our results have thereby provided new insights into the structure-based selective rexinoids design with bigelovin as a potential lead compound.我们的研究结果由此提供了以与锦菊素为潜在先导化合物进行结构选择性rexinoids设计的启示。 |
10楼2012-05-22 16:48:38
