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carolhuhu

金虫 (正式写手)

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虫号: 544217
注册: 2008-04-12
专业: 化学生物学与生物有机化学

[交流] FW: positions available at HHMI Janelia Farm for research in neural circuits已有1人参与

Positions available at HHMI Janelia Farm with Albert Cardona:

1) Postdoc in physiology of identified neuronal connections

We have reconstructed with electron microscopy the neural circuitry
downstream of somatosensory neurons in fly larva. Each interneuron has
unique identity, being identifiable across individuals, and we have a
genetic driver line specific for each (hundreds!). Each neuron receives
a reasonably stereotyped number of synapses from specific, also
stereotyped somatosensory neurons and from other interneurons. The goal
is to quantify with electrophysiology and calcium imaging the effect of
a low or high number of synapses between two neurons, these being at
specific locations of their neuronal arbors, and considering the known
locations of GABAergic inputs as well on that arbor.

2) Software engineer or postdoc in computer vision

We reconstruct neuronal circuits from large-scale electron microscopy
image volumes [4]. As a postdoc, you would be developing novel
algorithms that improve on what is quoted below, and delivering proof of
principle implementations. As a software engineer you would generate
high-performance implementations of known algorithms, such as:

A) implement Saalfeld's elastic registration method for a cluster
(reference implementation exists in java [1], multithreaded). All
reference algorithms exist formalized as well in a paper that we are
about to publish.

B) implement Funke's neuronal reconstruction algorithm [2] as a
server-side process for CATMAID [3]. A reference implementation in C++
and java exists.

[1] One the java classes is
here: http://fiji.sc/cgi-bin/gitweb.cg ... esMesh.java;hb=HEAD . The rest of the code is spread within the mpicbg.git and the TrakEM2.git repositories, both public.
[2] Efficient Automatic 3D-Reconstruction of Branching Neurons from EM
Data. Jan Funke, Bjoern Andres, Fred A. Hamprecht, Albert Cardona,
Matthew Cook. CVPR 2012.
[3] http://catmaid.org
[4] See a small example: http://www.ini.uzh.ch/~acardona/data.html

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