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Johenson: ½ð±Ò+14, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸, Ì«¸øÁ¦ÁË£¡ 2012-04-26 12:36:59
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Johenson: ½ð±Ò+14, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸, Ì«¸øÁ¦ÁË£¡ 2012-04-26 12:36:59
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ΪʲôҪͶÕâ¸öÔÓÖ¾µÄjustifying£¨ÊÇcover letterµÄÒ»²¿·Ö£© We would like to submit the enclosed manuscript entitled "*", which we wish to be considered for publication in *. We believe that two aspects of this manuscript will make it interesting to general readers of *. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release. http://muchong.com/bbs/viewthread.php?tid=191002 |

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