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[求助] 求助美洛西林钠LD50

求助美洛西林钠的半数致死量为多少，请各位兄弟姐妹们帮忙，谢谢

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hongweiwei000: 金币+5, ★★★★★最佳答案, thank you for your help 2012-04-12 11:36:44

RTECS NUMBER          : XH9170000
CHEMICAL NAME          : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                        3,3-dimethyl-6-(((((3-(methylsulfonyl)-
                        2-oxo-1-imidazolidinyl)carbonyl)amino)phenylacetyl)am
                        ino)-7-oxo-, sodium salt,
                        (2S-(2-alpha,5-alpha,6-beta)(S*))-
CAS REGISTRY NUMBER    : 42057-22-7
LAST UPDATED          : 199509
DATA ITEMS CITED       : 13
MOLECULAR FORMULA    : C21-H24-N5-O8-S2.Na
MOLECULAR WEIGHT       : 561.61
WISWESSER LINE NOTATION : T45 ANV ESTJ F1 F1 GVO CMVYR&MV- AT5NVNTJ CSW1 &-NA-
                        &QH
COMPOUND DESCRIPTOR    : Drug
                        Reproductive Effector
SYNONYMS/TRADE NAMES :
* Antibiotic bay-f 1353
* Mezlocillin
* Mezlocillin sodium
* Sodium mezlocillin hydrate

                     *** HEALTH HAZARD DATA ***

                     ** ACUTE TOXICITY DATA **

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Oral
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : >20 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,513,1979

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Subcutaneous
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : >16 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,513,1979

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : 2636 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,513,1979

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Oral
SPECIES OBSERVED       : Rodent - mouse
DOSE/DURATION          : >16 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,513,1979

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Subcutaneous
SPECIES OBSERVED       : Rodent - mouse
DOSE/DURATION          : >16 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,513,1979

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Rodent - mouse
DOSE/DURATION          : 6329 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,513,1979

               ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST          : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : 60 gm/kg/5W-I
TOXIC EFFECTS :
Blood - hemorrhage
Skin and Appendages - dermatitis, other (after systemic exposure)
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,513,1979

TYPE OF TEST          : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : 124800 mg/kg/13W-I
TOXIC EFFECTS :
Blood - hemorrhage
Skin and Appendages - dermatitis, other (after systemic exposure)
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,513,1979

TYPE OF TEST          : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : 291 gm/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Nutritional and Gross Metabolic - changes in sodium
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967-  Volume(issue)/page/year: 17,535,1979

                        ** REPRODUCTIVE DATA **

TYPE OF TEST          : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Rodent - rat
DOSE                   : 81 gm/kg
SEX/DURATION          : male 60 day(s) pre-mating
                        female 14 day(s) pre-mating  - 7 day(s) after
                        conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970-
Volume(issue)/page/year: 9,981,1978

TYPE OF TEST          : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Rodent - rat
DOSE                   : 2750 mg/kg
SEX/DURATION          : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970-
Volume(issue)/page/year: 9,986,1978

TYPE OF TEST          : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE    : Intravenous
SPECIES OBSERVED       : Rodent - rat
DOSE                   : 5500 mg/kg
SEX/DURATION          : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970-
Volume(issue)/page/year: 9,986,1978

      *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
   NOES Hazard Code - X5309
   No. of Facilities: 7 (estimated)
   No. of Industries: 1
   No. of Occupations: 2
   No. of Employees: 307 (estimated)
   No. of Female Employees: 251 (estimated)

                        *** END OF RECORD ***

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