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【答案】应助回帖
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smth: 金币+1, 博学EPI+1, ★有帮助, 不知只有你会用 GOOGLE 的 2012-04-10 13:08:15
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Benzo oxazole and dihydro-pyrazole compound is a core structural unit of many pesticides and medicine.Benzoxazole is widespread in nature, it has important pharmacological activity is an important intermediate of pharmaceutical chemistry, benzoxazole derivatives as cytotoxic inhibitors, protease inhibitors and reverse transcriptase inhibitors,benzoxazole ring derivatives other applications include herbicides, fluorescent brighteners; five heterocyclic compounds dihydro-pyrazole and its derivatives is an important intermediate of pesticide and medicine, has bactericidal, insecticidal and herbicidalother active pyrazole compounds showed good antibacterial, anti-tuberculosis, anti-tumor, anti-HIV-1 and anti-cancer activity.How simple methods starting from simple materials to build these skeleton units has been a goal of chemists have. Although there are several ways to synthesize these compounds, but they are common to many of the shortcomings, or expensive catalyst or reaction steps are too cumbersome, or precursors difficult preparation, the development of a from the simple the raw materials starting after a short synthetic steps to build these heterocyclic compounds is still of great significance. In this thesis, from simple raw materials such as nitrile, olefin starting a new synthetic method for the use of tandem reactions to construct the benzoxazole and dihydro-pyrazole ring. |
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