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lingyun79

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[资源] RSC07最新J. Mater. Chem.关于 maghemite–organosilica 微球的最新报道

Journal of Materials Chemistry, 2007年 3月24日

Mesoporous maghemite–organosilica microspheres: a promising route towards multifunctional platforms for smart diagnosis and therapy

Beatriz Julián-López, Cédric Boissière, Corinne Chanéac, David Grosso, Sebastien Vasseur, Sylvain Miraux, EtienneDuguetand Clément Sanchez*

Abstract
We report facile fabrication of advanced hybrid silica–spinel iron oxide (maghemite) composite microspheres
built with both superparamagnetic nanoparticles for MR imaging, hyperthermia, and a hybrid mesoporous matrix
enabling the transport of bioactive molecules for in vivo biomedical applications. Elaboration of such
multifunctional platforms is performed by spray drying a sol of tunable composition that allows one to control the
size and amount of magnetic particles embedded in the matrix, without aggregation, and to adjust the size and the
surface chemical properties of the porous silica cavities. The resulting nanocomposites ( -Fe2O3 8 nm particles in
silica matrices from TEOS templated by CTAB or P123, without or with functionalisation with –Ph, –SH or –
NH2) were characterised by chemical analysis, XRD, TEM, BET, FTIR and magnetisation measurements. Tests of
the materials both as MRI T2-contrast agents and as heating sources of hyperthermia are presented in support of
potential applications in diagnosis and therapy.

[ Last edited by popsheng on 2007-4-22 at 12:35 ]

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