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canfeng2008

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Sirtuin 1 (SirT1), the mammalian homolog of yeast silent information-regulator 2 (Sir2), is an NAD+-dependent histone deacetylase and an important coordinator of the mammalian metabolic response to fasting and caloric restriction (10–12). During periods of nutrient deprivation, elevated levels of SirT1 in the liver increase hepatic glucose production (10) and induce the expression of oxidative machinery (13). Accordingly, experimental knockdown of SirT1 reduces fasting plasma glucose levels and increases whole-body insulin sensitivity by reducing hepatic glucose production (11,14). In adipose tissue, SirT1 enhances metabolic efficiency by promoting adiponectin production (15). Conversely, adipocyte SirT1 expression is suppressed by high-fat feeding in rodents (16), and its levels are also markedly reduced in the adipose tissue of obese humans and genetically obese rodents (16,17).
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清风-865

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爱与雨下: 金币+1 2012-04-12 12:14:32
爱与雨下: , 欢迎交流! 2012-04-12 12:14:49
sltmac: 金币+10, 翻译EPI+1 2012-04-15 16:08:30
去乙酰化酶 1(SirT1),哺乳动物同系物的沉默信息调节者,是一个脱乙酰酶辅酶NAD +组和重要的协调员哺乳动物代谢反应空腹和热量限制(10 - 12)。营养不足期间,高浓度的SirT1在肝脏增加肝脏葡萄糖产量(10),诱导表达的氧化机械(13)。因此,实验击倒的空腹血糖水平SirT1减少,增加胰岛素敏感性降低全身性肝脏葡萄糖产量(11、14)。在脂肪组织,增强代谢效率,促进SirT1脂联素生产(15)。相反,脂肪细胞表达的是抑制SirT1高脂肪喂食啮齿类动物(16),其水平也明显减少脂肪组织的肥胖的人类和遗传性肥胖啮齿类动物(16、17)。
参考一下吧!!!
2楼2012-04-04 14:04:26
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