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（限3000 characters） 我国属于乙型肝炎高流行区，乙肝病毒（HBV）携带者约占总人口的10%。抗HBV药物是治疗慢性乙型肝炎的主要手段。目前临床上抗HBV药物的种类和数量有限，并且结构上多属于核苷类抗病毒药物，长期应用易引起病毒株耐药性的出现。研究和开发新型结构的抗乙肝病毒药物具有重要意义。课题组将1,2-苯并异噻唑酮结构引入5-羟基吲哚的2位，并参考前期化合物的设计思想，在5-羟基吲哚的２位上引入1,2,4-三氮唑基、四氮唑基，设计并合成了多种结构系列的化合物。课题组拟对其进行深入研究，利用新药设计原理，对多个结构位点进行改造和修饰，设计并合成50-60个化合物，在体外活性测试的基础上，探讨化合物的构效关系，建立具有较高预测能力的药效团模型，指导后续化合物的设计。 [ Last edited by liuzijian on 2012-3-6 at 09:11 ] |
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清风流水楚辞
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| 前半部分：Our country belongs to hepatitis B high epidemic area, hepatitis B virus (HBV) carriers about 10% of the total population. Drug treatment of HBV is the main method of chronic hepatitis B. At present the type and quantity of clinical drug resistant HBV is limited, and the structure is nucleoside antiviral drugs, so long-term application will easily cause the emergence of resistant strains. |
2楼2012-03-06 09:40:20
清风流水楚辞
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★ ★ ★ ★ ★
sltmac(金币-5, 违规存档): 机器翻译，初犯，扣5金币予以警告~ 2012-03-06 12:54:32
sltmac(金币-5, 违规存档): 机器翻译，初犯，扣5金币予以警告~ 2012-03-06 12:54:32
| 后半部分：Our research group will be 1, 2-benzene and Margaret vision with structure into 5-hydroxyl of indoles 2, and the design idea of the compound reference, in 5-hydroxyl two of indoles into 1, 2, 4-triazole with 3/4-(nitrogen) was designed and synthesized compounds of structure series. To research to further study, using the new drug design principle of multiple structure transformation and modification reagents, design and synthesis of 50-60 compounds, the in vitro activity on the basis of the test, and this paper discusses the compounds structure-activity relationship, to establish a team with high ability to predict the pharmacophore models, guiding the design of the subsequent compounds. |
3楼2012-03-06 09:57:19
清风流水楚辞
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4楼2012-03-06 10:15:00
清风流水楚辞
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★
Mally89(金币+1): 感谢应助！~欢迎常来！~吼吼！~\(^o^)/~ 2012-03-06 12:08:57
Mally89(金币+1): 感谢应助！~欢迎常来！~吼吼！~\(^o^)/~ 2012-03-06 12:08:57
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完整全篇如下： Our country belongs to hepatitis B high epidemic area, hepatitis B virus (HBV) carriers about 10% of the total population. Drug treatment of HBV is the main method of chronic hepatitis B. At present the type and quantity of clinical drug resistant HBV is limited, and the structure is nucleoside antiviral drugs, so long-term application will easily cause the emergence of resistant strains. Research and development of new structure with anti-hepatitis B virus medicine has important significance. Our research group will be 1, 2-benzene and Margaret vision with structure into 5-hydroxyl of indoles 2, and the design idea of the compound reference, in 5-hydroxyl two of indoles into 1, 2, 4-triazole with 3/4-(nitrogen) was designed and synthesized compounds of structure series. To research to further study, using the new drug design principle of multiple structure transformation and modification reagents, design and synthesis of 50-60 compounds, the in vitro activity on the basis of the test, and this paper discusses the compounds structure-activity relationship, to establish a team with high ability to predict the pharmacophore models, guiding the design of the subsequent compounds. 希望对你有用，能有重要参考价值 |
5楼2012-03-06 10:17:01
6楼2012-03-06 12:50:49
miaozhen1771
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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
liuzijian(金币+100, 翻译EPI+1): ★★★★★最佳答案 非常感谢，支持原创！ 2012-03-07 15:26:48
liuzijian(金币+100, 翻译EPI+1): ★★★★★最佳答案 非常感谢，支持原创！ 2012-03-07 15:26:48
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我国属于乙型肝炎高流行区，乙肝病毒（HBV）携带者约占总人口的10%。 China have high HIV ratios，HBV carriers account for 10% of the population. 抗HBV药物是治疗慢性乙型肝炎的主要手段。 Anti HBV drug is the mainly treatment to cure chronic HBV. 目前临床上抗HBV药物的种类和数量有限，并且结构上多属于核苷类抗病毒药物，长期应用易引起病毒株耐药性的出现。 At present, anti HBV drugs are very limited in type and quantity, and are almost nucleoside antiviral drugs in structure, which can induce drug resistance of virus. 研究和开发新型结构的抗乙肝病毒药物具有重要意义。 It has very important meaning to research and develop the new structure anti HBV drug. 课题组将1,2-苯并异噻唑酮结构引入5-羟基吲哚的2位，并参考前期化合物的设计思想，在5-羟基吲哚的２位上引入1,2,4-三氮唑基、四氮唑基，设计并合成了多种结构系列的化合物。 The research team add the 1,2-苯并异噻唑酮 to 2-site of 5-羟基吲哚, and refer to the primary design idea of compound, add 1,2,4-三氮唑基、四氮唑基 to this site and synthesize series compound of multiply structure. 课题组拟对其进行深入研究，利用新药设计原理，对多个结构位点进行改造和修饰，设计并合成50-60个化合物，在体外活性测试的基础上，探讨化合物的构效关系，建立具有较高预测能力的药效团模型，指导后续化合物的设计。 The research group will perform the deeper research to use principle of new drug investigation to transform and modify multi structure sites, through this the group design and synthesize 50~60 compounds, based on the activity test in vitro to detect the structure- activity relationship of compounds, and to build the effective module with high prediction ability, to induct the consequent design process. 虽然晚了，希望有帮助。 |
7楼2012-03-06 12:59:55
liufuliang
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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
liuzijian(金币+100): ★★★★★最佳答案 非常非常感谢，支持原创！ 2012-03-07 15:27:14
liuzijian(金币+100): ★★★★★最佳答案 非常非常感谢，支持原创！ 2012-03-07 15:27:14
|
上面这位翻译的不错。有一些小的问题，我帮忙改一下！ 1、我国属于乙型肝炎高流行区，乙肝病毒（HBV）携带者约占总人口的10%。 China have high HIV ratios，HBV carriers account for 10% of the population. 改成： China has high ratio of HBV carriers which account for 10% of the population. 2、抗HBV药物是治疗慢性乙型肝炎的主要手段。 Anti HBV drug is the mainly treatment to cure chronic HBV. 改成：Anti-HBV drug is the main treatment to cure chronic HBV. 3、目前临床上抗HBV药物的种类和数量有限，并且结构上多属于核苷类抗病毒药物，长期应用易引起病毒株耐药性的出现。 At present, anti HBV drugs are very limited in type and quantity, and are almost nucleoside antiviral drugs in structure, which can induce drug resistance of virus. 改成：At present, available anti-HBV drugs are very limited in type and quantity and almost belong to nucleoside antiviral drugs in structure, which can lead to virus strains with drug resistance. 3、研究和开发新型结构的抗乙肝病毒药物具有重要意义。 It has very important meaning to research and develop the new structure anti HBV drug. 改成：It is of very importance in research and development of new structure anti-HBV drug. 4、课题组将1,2-苯并异噻唑酮结构引入5-羟基吲哚的2位，并参考前期化合物的设计思想，在5-羟基吲哚的２位上引入1,2,4-三氮唑基、四氮唑基，设计并合成了多种结构系列的化合物。 The research team add the 1,2-苯并异噻唑酮 to 2-site of 5-羟基吲哚, and refer to the primary design idea of compound, add 1,2,4-三氮唑基、四氮唑基 to this site and synthesize series compound of multiply structure. 改成： The research team introduced 1,2-benzisothiazolone to 2-site of 5-cyanoindole. Based on the previous design idea of compound, 1,2,4-triazole and tetrazole were introduced to this site to synthesize series of compound of multiple structures. 5、课题组拟对其进行深入研究，利用新药设计原理，对多个结构位点进行改造和修饰，设计并合成50-60个化合物，在体外活性测试的基础上，探讨化合物的构效关系，建立具有较高预测能力的药效团模型，指导后续化合物的设计。 The research group will perform the deeper research to use principle of new drug investigation to transform and modify multi structure sites, through this the group design and synthesize 50~60 compounds, based on the activity test in vitro to detect the structure- activity relationship of compounds, and to build the effective module with high prediction ability, to induct the consequent design process. 改成： The research team is intended to perform the deeper research: according to the principle of new drug,multiple structure sites will be transformed and modified to design and synthesize 50~60 compounds; based on the activity test in vitro, the structure-activity relationship of compounds will be explored and discussed to build the effective module with high prediction ability for guiding the consequent design process. |
8楼2012-03-07 00:59:54
5