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The efficacy and safety of rosuvastatin on short-term treating the aged coronary heart disease patients with diabetes mellitus
¡¾Abstract¡¿Background To evaluate the efficacy and safety of statins on short-term treating coronary heart disease patients with diabetes mellitus aged 75 years or older and compare its effects with different doses of atorvastatin simultaneously. Methods A randomized single-blind parallel controlled study was conducted in 116 aged coronary heart disease patients with diabetes mellitus£®The patients were randomly divided into control group and statin treatment groups; receives conventional treatment£¬rosuvastatin 10mg/d£¬atorvastatin 10mg/d or 20mg/d for two weeks£®Results Levels of fasting plasma APN(adiponectin), hs-CRP(high-susceptible C reactive protein), TC£¬TG£¬LDL-C£¬HDL-C£¬ALT(alanine transarninase)£¬AST(aspartate aminotransferase)£¬CR(creatinine) and CPK(creatine phosphokinase) were tested before and after the treatment. Moreover£¬the adverse reactions of patients in statins treatment groups wereobserved£®The results show that the LDL-C level decreased significantly in statin treatment groups(P<0.05)£®Furthermore, the APN and hs-CRP level changed in rosuvastatin group and 20mg/d atorvastatin group£® For four treatment groups£¬the hepatorenal function and CPK level hadn¡¯t significantly changed£®Conclusion It was concluded that rosuvastatin 10mg/d was more effective than atorvastatin 10mg/d and 20mg/d in lipid-lowering and non-lipid-lowering on short term treating the aged coronary heart disease patients with diabetes mellitus based upon the results.  However£¬the safety data was similar outcome between them according to a 2-week follow-up study.
¡¾Key Words¡¿ Rosuvastatin£»Atorvastatin£»Coronary Disease£»Diabetes Mellitus£»Treatment Outcome
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vigorous

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