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[资源] Receptor - Based Drug Design

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Receptor - Based Drug Design

Title: Receptor - Based Drug Design (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs)
Author: Paul Leff
Publisher: CRC
Publication Date: 1998-04-01
Number Of Pages: 400
Average Amazon Rating:
Hardcover: 400 pages
Publisher: CRC (April 1, 1998)
Language: English
ISBN: 0824701623

Review
" …valuable…provide[s ] information about established drugs as well as a number of drugs set to enter the marketplace or that are undergoing the approval process. The work is certainly current and definitive, and it contains chapters written by a number of well-known authorities in industry and acdemics. "-Pharmaceutical Technology, 1999 "…this volume is essential reading for the users of the libraries of pharmaceutical companies and university departments of pharmacology, pharmacy, and medicinal chemistry. "-Journal of Medicinal Chemistry

Book Description
Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design.Explains the experimental and theoretical methods used to characterize interactions between ligands and receptors-providing the pharmacological information needed to solve treatment problems and facilitate the drug design process!Demonstrating the achievements of the receptor-based approach in therapeutics and indicating future directions, Receptor-Based Drug Designintroduces novel computer-assisted strategies for the design of new agonists, antagonists, and inverse agonists for G-protein-coupled receptorsshows how to assess agonist concentration-effect curve datadiscusses radioligand binding assayspresents new in vitro multiarray assays for G-protein-coupled receptorsexplains the use of individual second messenger signaling responses in analyzing drug-receptor interactionsexamines the role of electrophysiology in finding new drugs and drug targetsdescribes selectively acting b-adrenoceptor agonists and glucocorticoid steroids for asthma treatmentoutlines the rationale for using angiotensin receptor antagonistsand more!Written by over 25 international authorities and containing nearly 1200 bibliographic citations, Receptor-Based Drug Design is a practical resource for pharmacologists, pharmacists, and pharmaceutical scientists; organic and medicinal chemists and biochemists; molecular biologists; biomedical researchers; and upper-level undergraduate and graduate students in these disciplines.

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