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Create chemical entities made up of many identicalcomponents arranged

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Create self-replicating molecules and self-correctting Chemical react-

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errors introduced in the product are deleted and corrected£®

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Understand the nature of a given or desired new chemicaltransformation

sufficiently well that a catalyst for the reaction can be designed in

a rational manner£®

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Explore the chemistry at interfaces and control the stereochemistry of

heterogeneous catalysts used as bulk species£®

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Harness supramolecular constructs to preserve the integrity of chemi-

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Use parallel automated synthesis or combinatorial trial-and error

reactions to improve on a chemical transformation in an evolutionary

manner£®

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Control the direction and orientation of the approach of one molecule

reacting with another£®

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Understand the internal motions of molecules so that£¬with appropriate

timing£¬a pulse of electromagnetic energy can be used to dissociate

specifically a chosen bond in the molecule

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Understand the structure and dynamics of inter-molecular interactions

so that the properties of molecular collections can be predicted and

controlled£®

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Devise reagents and pathways for breaking into chemical bonds previou-

sly considered to be inert£®

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Find the means for converting naturally abundant substances into

chemically useful small-molecule building blocks and vice versa£®

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Develop the art of conducting chemical reactionswithout solvents£®

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Create reagents that chemically modify a portion of a molecle without

protecting£® and later having to deprotect£¬ other reactive sites on

the molecule that we do not want to modify.

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Create chemical products and processes that do notrequire the use or

generation of hazardous substances and that use renewable resources£®

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Understand and harness the properties of compounds of intermediate(1-

100nm) size between the mo1ecular and solid state.

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Investigate the chemistry of single isolated molecules and compare the

properties with those of an ensemble of such molecules and in various

solvents£®

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Create molecules that self-assemble into supramolecular structures

including solids£¬the properties of which surpass those of the

molecular collection£®

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Learn how to grow crystalline solids of molecules of any composition

and to incorporate guests into these crystals to enhance their physi-

cal and chemical properties£®

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Discover unusual compositions of matter comprising chemical elements

and fundamental particles in combinations not previously encountered£®

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Master the chemistry of caged species£¬releasing at will a guest entr-

apped in an appropriatehost in the gas,solution£®or solid state by

introducing a chemical£¬magnetlc or electric field£®

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Understand and use the chemistry energetics and spectroscopy of poly-

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Evolve new theoretical approaches to understand chemical bonding and

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