The Handbook of Fungal Biotechnology offers the newest developments from the frontiers of fungal biochemical and molecular processes and industrial and semi-industrial applications of fungi. This second edition highlights the need for the integration of a number of scientific disciplines and technologies in modern fungal biotechnology and reigns as the top source on current molecular, biochemical, and medical technologies and commercial usages for fungi. Authored by 81 world-renowned scientists from both industry and academia, it addresses contemporary issues pertaining to intellectual property rights, biodiversity, and biosafety, and devotes an entire section to medical biotechnology.

Preface
Contributors
1 Cell Biology of Hyphae 1
2 Protoplast Isolation, Regeneration, and Fusion in Filamentous Fungi 9
3 Metabolic Pathway Regulation 25
4 Fungal Nuclei and Chromosomes 39
5 Genomics of Filamentous Fungi: A General Review 55
6 Stability and Instability of Fungal Genomes 69
7 Secondary Metabolic Gene Clusters in Filamentous Fungi 81
8 Application of Gene Cloning in Fungal Biotechnology 95
9 Transformation and Gene Manipulation in Filamentous Fungi: An Overview 109
10 Genetic Manipulation Systems for Nonconventional Fungi 121
11 Fungal Mitochondria: Genomes, Genetic Elements, and Gene Expression 131
12 Fungal Evolution Meets Fungal Genomics 145
13 Genome Sequence Patterns and Gene Regulation: A Bioinformatics Perspective 163
14 DNA Chips and Microarray Analysis: An Overview 173
15 Signal Transduction in Fungi: Signaling Cascades Regulating Virulence in Filamentous Fungi 181
16 Application of Genetic Engineering for Strain Improvement in Filamentous Fungi 193
17 The Genetic Improvement of Wine Yeasts 209
18 Fungi in Brewing: Biodiversity and Biotechnology Perspectives 233
19 Ethanol-Tolerance and Production by Yeast 249
20 Solid-State Fermentation: An Overview 267
21 Basic Principles for the Production of Fungal Enzymes by Solid-State Fermentation 275
22 Commercial Importance of Some Fungal Enzymes 287
23 Xylanases of Thermophilic Molds and Their Application Potential 299
24 Chitin Biosynthesis in Fungi 315
25 Bioactive Fungal Polysaccharides and Polysaccharopeptides 331
26 Biotechnological Potential of Fungal Lipids 341
27 Introduction to the Theory of Metabolic Modeling and Optimization of Biochemical Systems: Application to Citric Acid Production in Aspergillus niger 353
28 Fungal Carotenoid Production 367
29 Fungal Terpenoid Antibiotics and Enzyme Inhibitors 379
30 Commercial Production and Biosynthesis of Fungal Antibiotics: An Overview 401
31 Molecular Biology of Trichoderma and Biotechnological Applications 413
32 Plectomycetes: Biotechnological Importance and Systematics 429
33 Exploitation of GFP-Technology with Filamentous Fungi 441
34 Antifungal Drugs in Fungal Infections 453
35 Antitumor and Immunomodulatory Compounds from Fungi 469
36 Clinical and Laboratory Diagnosis of Fungal Infections 479
37 Candidiasis 493
38 Immunizations Against Fungal Diseases in Man and Animals 503
39 Fungal Allergy 515
40 Current Status of Fungal Collections and Their Role in Biotechnology 527
41 Benefits and Risks of Genetically Modified Foods: An Overview 539
42 Transgenic Mycoherbicides: Needs and Safety Considerations 549
43 Recent Developments in Biotechnology and Intellectual Property, Access to Genetic Resources, and Benefit-Sharing 565
Index 575

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