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11月 Science最新的2篇review~
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The Big and the Small: Challenges of Imaging the Brain’s Circuits Jeff W. Lichtman1,*, Winfried Denk2,* Abstract The relation between the structure of the nervous system and its function is more poorly understood than the relation between structure and function in any other organ system. We explore why bridging the structure-function divide is uniquely difficult in the brain. These difficulties also explain the thrust behind the enormous amount of innovation centered on microscopy in neuroscience. We highlight some recent progress and the challenges that remain. The Cell Biology of Synaptic Plasticity Victoria M. Ho1, Ji-Ann Lee2, Kelsey C. Martin2,3,4,* Abstract Synaptic plasticity is the experience-dependent change in connectivity between neurons that is believed to underlie learning and memory. Here, we discuss the cellular and molecular processes that are altered when a neuron responds to external stimuli, and how these alterations lead to an increase or decrease in synaptic connectivity. Modification of synaptic components and changes in gene expression are necessary for many forms of plasticity. We focus on excitatory neurons in the mammalian hippocampus, one of the best-studied model systems of learning-related plasticity.[ Last edited by lchpy on 2011-11-4 at 20:31 ] |
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