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2000ÄêSperandioµÈÔÚ293Tϸ°ûϵÖ㬱í´ïÒȵºËØÑùÉú³¤Òò×Ó1ÊÜÌ壨IGFIR£©Ê±·¢ÏÖÒ»ÖÖÓë¾µäµòÍö²»Í¬µÄËÀÍö±íÐÍ£¬²¢¶¨ÒåΪParaptosis¡£[4] [4] Sperandio S,de Belle I,Bredesen DE.An alternative,nonapoptotic form of programmed cell death.[J].Proc Natl Acad Sci.2000;97:14376-14381.ParaptosisµÄÐÎÌ¬Ñ§ÌØÕ÷ÊÇϸ°û½¬¿ÕÅÝ»¯£¬ÏßÁ£ÌåºÍÄÚÖÊÍøÖ×ÕÍ£¬µ«Ã»Óк˹ÌËõÏÖÏó¡£
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1989Ä꣬Lisa Molz [5] [5] Molz L,Booher R,Young P,et al.Cdc2 and the regulation of mitosis:six interacting mcs genes.[J].Genetics.1989,122:773-782.µÈ·¢ÏÖÔÚ½ÍĸµÄÒ»ÖÖ¶ÔÈÈÃô¸ÐµÄÍ»±äÖêÖУ¬Ï¸°û·ÖÁÑʱȾɫÌå·ÖÀë·¢ÉúÒì³£¡£ÏàÓ¦µÄһЩѧÕß±ã°ÑÕâÖÖÔÚDNA·¢ÉúËðº¦Ê±£¬Ï¸°ûÎÞ·¨½øÐÐÍêÈ«µÄ·ÖÁÑ´Ó¶øµ¼ÖÂËı¶Ìå»ò¶à±¶ÌåµÄÏÖÏó³ÆÎªÏ¸°ûÓÐË¿·ÖÁÑÔÖÄÑ[6] [6] Margottin-Goguet F,Hsu JY,Loktev A,et al.Prophase destruction of Emi1 by the SCF (betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.[J].Dev Cell.2003,4:813-826.¶ÔÓÚϸ°ûÓÐËÀ·ÖÁÑÔÖÄѵÄÐÎÌ¬Ñ§ÌØµãÃèÊö²¢²»ÊǺÜÍêÈ«£¬µ«Ö÷ÒªÊǾÞϸ°ûµÄÐγɣ¬ÄÚÓжà¸öСºË£¬È¾É«ÖÊÄý¾Û¡£ÓÐË¿·ÖÁÑÔÖÄѺ͵òÍöµÄȾɫÌå¹ÌËõÊÇ·ñÒ»Ñù£¬ÏÖÔÚ¿´·¨²¢²»Ò»Ö¡£DNA·¢ÉúËðº¦Ê±£¬Èç¹ûϸ°û²»ÄÜÓÐЧµØ×è¶ÏÆäϸ°ûÖÜÆÚµÄ½øÐУ¬»áµ¼ÖÂȾɫÌåµÄÒì³£·ÖÀ룬ÕâЩ·ÇÕý³£·ÖÁѵÄϸ°ûÔÚÏÂÒ»ÂÖÓÐË¿·ÖÁÑÖлá¼ÌÐøµ¼ÖÂϸ°û¶à±¶ÌåµÄÐγɴӶø³ÉΪ°©±äµÄ»ù´¡¡£¶øÏ¸°ûÓÐË¿·ÖÁÑÔÖÄÑ×÷ΪһÖÖËÀÍö»úÖÆ¿ÉÒÔʹÕâÖÖ·ÇÕý³£·ÖÁѵÄϸ°ûËÀÍö¡£Ï¸°ûÓÐË¿·ÖÁÑÔÖÄÑÓɶàÖÖ·Ö×Óµ÷¿Ø£¬ÈçCDK1£¬P53¼°SurvivinµÈ£¬ÆäËÀÍöÐźŴ«µÝÓкܴóÒ»²¿·ÖÓëµòÍöÏàÖØµþ¡£ |
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