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ÎÄÏ×ÌâÄ¿Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals
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juliana_zou11

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ÕâÆªÎÄÕµÄÒâ˼Êǽ²¸øÐ¡ÊóÒ»¸öÌØ¶¨µÄ»·¾³´Ì¼¤£¬¿´´Ì¼¤ÒýÆðµÄ´úл»ùÒòµÄ±í´ïÔÚºó´úСÊóÖÐÊDz»ÊÇ»¹Æð×÷ÓÃ
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Epigenetic information can be inherited through the
mammalian germline and represents a plausible
transgenerational carrier of environmental information.
To test whether transgenerational inheritance
of environmental information occurs in mammals, we
carried out an expression profiling screen for genes
in mice that responded to paternal diet. Offspring
of males fed a low-protein diet exhibited elevated
hepatic expression of many genes involved in lipid
and cholesterol biosynthesis and decreased levels
of cholesterol esters, relative to the offspring of males
fed a control diet. Epigenomic profiling of offspring
livers revealed numerous modest (20%) changes
in cytosine methylation depending on paternal diet,
including reproducible changes in methylation over
a likely enhancer for the key lipid regulator Ppara.
These results, in conjunction with recent human
epidemiological data, indicate that parental diet can
affect cholesterol and lipid metabolism in offspring
and define a model system to study environmental
reprogramming of the heritable epigenome.
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