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[资源] 2010年wiley公司出版的一本很全很新的生物分析领域书籍

Edited by David T. Pierce and Julia Xiaojun Zhao
Trace Analysis with Nanomaterials
Wiley-VCH Verlag GmbH & Co. KGaA

Introduction:
Trace analysis is an important topic that impacts various areas ranging from
environmental monitoring to national security, food safety, clinical diagnosis, and
forensic investigation. The need for sensitive and robust determinations in these
areas has driven a rapid development of novel nanomaterials as well as new
methodologies with which to implement them. Unfortunately, essential details of
these new nanomaterials and approaches for their use have largely remained in
wide - ranging journals and specialized compilations. Our goal for this book has
been to provide an introduction to these new methods and materials in one source
and thereby encourage the development of new, cross - disciplinary ideas among
scientists from many different fi elds. Accordingly, this book includes a broad
cross - section of nanomaterial - based methodologies and applications. Selected
topics are reviewed in 14 chapters and organized in three sections.
Section I (Chapters 1 – 5 ) is dedicated to “ Biological and Chemical Analysis. ” The
performance of biosensors and bioassays has been aided by the rapid development
of nanotechnology and the application of various nanomaterials. Chapters 1 and
2 are focused on photoactive nanomaterials. Chapter 1 summarizes recent advances
of photoswitchable nanoprobes that feature changes in fl uorescence and magnetization.
Contributions of these nanoprobes to super - resolution fl uorescence
imaging and acquisition of quantitative information of biological targets are
reviewed. Semiconductor quantum dot s ( QD s) have attracted considerable attention
in the fi elds of chemistry and biology over the past decade. Based on these
recent advances, Chapter 2 reviews the fundamental properties, characteristic
advantages, and synthetic methods for various semiconductor QDs. Several
successful analytical applications of QDs in the fi eld of chemistry and biology are
discussed.
Chapters 3 and 4 emphasize nanomaterials - based electrochemical biosensors
and bioassays. The enormous signal enhancement associated with the use of
nanomaterial labels and the formation of nanomaterial – biomolecule complexes
provides the basis for ultrasensitive electrochemical detection of disease - related
gene or protein markers, biothreat agents, or infectious agents. Chapter 3 discusses
various nanomaterials for bioanalysis, including nanoparticles, nanowires,
nanotubes, and nanocarriers. The surface - dependent electron transport properties
of nanomaterials are often used to develop chemical and biological sensors for
XIV Preface
trace analysis. Specifi cally, physical and/or chemical sorption of analytes on a
nanomaterial surface may affect the rates of electron transport through a nanomaterial
assembly, resulting in detectable change in its electronic conductivity. In
Chapter 4 , the authors review chemical and biological sensing applications based
on electron transport through nanoparticle assemblies.
In addition to nanomaterials, nanodevices based on fl uidics have reduced signifi
cantly the time and costs involved in chemical/biochemical experimentation.
They have also permitted the study of several physical/chemical/biological systems
at a fundamentally higher level. In Chapter 5 , the authors describe applications of
micro - and nanofl uidic technology to the trace analysis of biological samples with
a focus on assays involving nucleic acids, proteins/peptides, and biological cells.
Section II (Chapters 6 – 10 ) is dedicated to “ Environmental Analysis. ” Nanomaterials
have shown great potential for improving the detection and extraction
of trace contaminants in the environment, but they may themselves pose an environmental
hazard if released. Chapter 6 focuses on the analysis of water contaminated
with endocrine - disrupting chemicals by the use of molecularly imprinted
polymer s ( MIP s). This chapter gives an overview of signifi cant achievements to
improve the performance of MIPs in solid - phase extraction using particles during
the last two years. Chapter 7 reviews current research on trace detection and
quantifi cation of nitrated and peroxide - based high explosives with various techniques
involving nanomaterials. In particular, sensors based on electrochemistry,
fl uorescence, microcantilevers, and metal oxide semiconductive nanoparticles are
discussed.
Hazardous metals are another important class of environmental pollutants. The
authors of Chapter 8 survey the use of nanostructured materials for the selective
collection of trace - level metals from aqueous systems. It has been shown that,
when correctly constructed, these nanomaterials are superior sorbents and can be
used to enhance trace level analysis. In addition to newly developed nanomaterials,
some traditional nanomaterials, such as TiO 2 , have demonstrated new applications
for trace detection, particularly in environmental analysis. Several TiO 2 - based
nanostructures important in analysis applications are introduced in Chapter 9 ,
including colloidal and mesoporous TiO 2 nanoparticles, TiO 2 nanotubes, TiO 2 -
based hybrids, and TiO 2 nanofi lms. Also described are sample pretreatment and
analyte preconcentration methods based on the strong adsorption of organic and
inorganic species onto TiO 2 nanomaterials.
In Chapter 10 the authors bring an interesting perspective to the use of engineered
nanoparticle s ( ENP s). Not only are recent advances in the use of ENPs for
environmental sensing described, but the environmental fate and toxicity of ENPs
are also discussed.
Section III (Chapters 11 – 14 ) is dedicated to “ Advanced Methods and Materials. ”
Here the development of new nanomaterials and new methods for trace analysis
are discussed. In Chapter 11 , a wide variety of analytical methods employing
electrodes modifi ed with nanoparticles are summarized. Chapter 12 focuses on
the analysis of single molecules or single events using nanoelectrodes and combined
optical and electrochemical methods.
Preface XV
Chapters 13 and 14 focus on the development and application of several new
nanomaterials. Membranes derived from block copolymer s ( BCP s) and containing
arrays of cylindrical nanoscale pores are described in Chapter 13 . Recent achievements
indicate that BCP - derived nanoporous monoliths are promising materials
to develop highly effi cient separation membranes for biomolecules and detection
devices with high selectivity and sensitivity. Chapter 14 introduces gold nanorod s
( AuNR s) and a broad range of applications that transcend the now - familiar gold
nanoparticle. The methods of synthesis and unique physicochemical characteristics
of AuNRs are described in detail and their most recent uses in trace analysis
are discussed.
We hope that you fi nd this book useful during your research and that it proves
helpful in developing new avenues for trace analysis. We certainly look forward to
receiving your feedback. Finally, and most especially, we wish to thank each of the
contributors to this book. Without their dedication and expertise, this work would
never have been possible.
Grand Forks, USA , January 2010 David T. Pierce
Julia Xiaojun Zhao[ Last edited by 西湖醉鱼 on 2011-9-12 at 13:23 ]

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