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求助有机翻译一段，谢谢各位大神
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| Within our research group we are interested in the development of previously undescribed synthetic methodologies that can be applied in a DOS context for the construction of libraries of structurally unique compounds with increased biological relevance.Toward this end, we wanted to explore the incorporation of structural motifs from known bioactive molecules (or isosteres thereof) into macrocyclic ring structures. In this paper we report the development of a DOS strategy for the generation of structurally based around biologically relevant macrocyclic peptidomimetic frameworks. In a proof-of-concept study this approach was applied to the synthesis of a library of 14 structurally diverse and complex compounds containing these motifs. The modular nature of the synthetic routes developed should enable their application in future DOS studies for the creation of larger libraries of these derivatives incorporating greater levels of structural diversity. In addition, we envisage that these chemistries will prove to be useful in a wide variety of other synthetic applications. |
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8814402: 能帮你就帮帮人家呗 2011-08-25 21:38:54
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2楼2011-08-25 21:19:52