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有机方面英译汉一段，3Q
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There are many biologically active molecules that contain cyclic peptide and peptidomimetic structural units including diketopiperazines (DKPs, the smallest possible cyclic peptides,Fig. 1) (49, 50). Many compounds incorporating macrocyclic peptides and peptidomimetics (51–54) are also known to be capable of modulating biological systems. Despite such valuable properties,macrocyclic peptides (indeed macrocyclic compounds in general) are arguably a poorly explored structural class within drug discovery (54), and such compounds are underrepresented in current small-molecule libraries. This relative paucity of compounds can be attributed primarily to synthetic intractability(54). Thus there is a need for the development of efficient methods of broad utility for the synthesis of a diverse range of macrocyclic peptides and peptidomimetics so that the biological usefulness of these structural moieties can be investigated and exploited further. |
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【答案】应助回帖
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爱与雨下(金币+1): ！！~~ 2011-08-26 11:12:09
gaoshihua(金币+20, 翻译EPI+1): 谢谢 2011-08-26 18:51:43
爱与雨下(金币+1): ！！~~ 2011-08-26 11:12:09
gaoshihua(金币+20, 翻译EPI+1): 谢谢 2011-08-26 18:51:43
| 有很多包含循环肽结构和peptidomimetic结构单位包括二酮哌嗪类（DKPs，肽类中最小的循环结构，Fig.1）[fig.这里不明白是什么意思]生物活性分子，许多化合物组合而成大环多肽和多肽模拟物（51-54）也被认为是有能力改变生物系统的。尽管有这样的价值属性，大环多肽（事实上是普遍的大环化合物）很少作为药物发现物（54）来探究其结构类型【structural class】，这类化合物在小分子库中也不具有被充分代表的趋势。少量的化合物被归类于难于合成的化合物。这样就需要对于大环肽类和多肽类模拟物具有广泛适用性的富有效率的不同范围类的综合分析方法的发展，这样对于这部分结构的生物应用研究与远期利用得以进行。 |
2楼2011-08-26 10:47:17
3楼2011-08-26 10:49:37