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【答案】应助回帖
wenzonglu(金币+5, 博学EPI+1): 谢谢啦帅哥靓妹 2011-08-20 21:35:33
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Anti-Tumor Activity of Polysaccharides Isolated from Patrinia scabra Bunge on U14 Cervical Carcinoma Bearing Mice
作者: Lu, WZ (Lu, Wen-Zong)1; Geng, GX (Geng, Guo-Xia)2; Li, QW (Li, Qing-Wang)1,3; Li, J (Li, Jian)3; Liu, FZ (Liu, Fu-Zhu)1; Han, ZS (Han, Zeng-Sheng)3; Gao, DW (Gao, Da-Wei)3; Yan, X (Yan, Xin)3; Yang, XL (Yang, Xiao-Lei)1
来源出版物: AMERICAN JOURNAL OF CHINESE MEDICINE 卷: 37 期: 5 页: 933-944 出版年: 2009
被引频次: 2 (来自 Web of Science)
引用的参考文献: 35 [ 查看 Related Records ] 引证关系图
摘要: The aim of our study was to investigate the effect of Patrinia scabra Bunge polysaccharide (PSB-P2) on cervical cancer cell (U14)-bearing mice. The tumor weight of mice treated with PSB-P2 (40, 80 mg/kg b.w.) was significantly lower than that of the control group and serum lactate dehydrogenase (LDH) activity was decreased, while serum alkaline phosphatase (AKP) level was only changed slightly. Meanwhile, the number of apoptotic tumor cells was significantly increased in the mice by the treatment of PSB-P2 (40, 80 mg/kg b.w.). At the same time, cell cycle analysis showed the accumulation of tumor cells in the G0/G1 phase and a relative decrease in the S phase. On the other hand, using the reverse transcription-polymerase chain reaction (RT-PCR) assay, PSB-P2 (40, 80 mg/kg b.w.) showed the up-regulation of p53 and Bax, and significant inhibition of Bcl-2 in tumor tissues. It suggests a possible mechanism of the inhibitory effect of PSB-P2 on tumor growth.
文献类型: Article
语种: English
作者关键词: Anti-Tumor; Polysaccharides; Patrinia scabra Bunge; Apoptosis; U14
KeyWords Plus: GASTRIC-CANCER; COLON-CANCER; APOPTOSIS; CELLS; TUMOR; EXTRACT; IMMUNOMODULATION; EXPRESSION; INDUCTION; MECHANISM
通讯作者地址: Li, QW (通讯作者),NW A&F Univ, Coll Anim Sci, Yangling 712100, Shaanxi, Peoples R China
地址:
1. NW A&F Univ, Coll Anim Sci, Yangling 712100, Shaanxi, Peoples R China
2. NW A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China
3. Yanshan Univ, Coll Environm & Chem Engn, Qinhuangdao 066004, Hebei, Peoples R China
电子邮件地址: ysulqw@126.com
基金资助致谢:
基金资助机构 授权号
Science and Technology Development Fund D08
Science and Technology Investing Company, Qinhuangdao, China
[显示基金资助信息][隐藏基金资助信息]
This Study was supported by the Science and Technology Development Fund (D08) of Science and Technology Investing Company, Qinhuangdao, China. The authors would like to thank Professor Zhao Jian-Cheng who examined and authenticated the used Patrinia scabra Bunge samples.
出版商: WORLD SCIENTIFIC PUBL CO PTE LTD, 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
JCR® 类别: Integrative & Complementary Medicine; Medicine, General & Internal
学科类别: Integrative & Complementary Medicine; General & Internal Medicine
IDS 号: 508TY
ISSN: 0192-415X |
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