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Fermentation and Biochemical Engineering Handbook
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Fermentation and Biochemical Engineering Handbook : Principles, Process Design, and Equipment Author: Henry C. Vogel Publisher: Noyes Publications Publication Date: 1996-10-01 Number Of Pages: 799 handbook of fermentation and biochemical engineering presenting the latest techniques for the commercial production of chemicals and pharmaceuticals via fermentation. Emphasis is given to unit operations fermentation, separation, purification, and recovery. Principles, process design, and equipment are detailed. Environment aspects are covered. The practical aspects of development, design, and operation are stressed. Theory is included to provide the necessary insight for a particular operation. Problems addressed are the collection of pilot data, choice of scale-up parameters, selection of the right piece of equipment, pinpointing of likely trouble spots, and methods of troubleshooting. The text, written from a practical and operating viewpoint, will assist development, design, engineering and production personnel in the fermentation industry. Contributors were selected based on their industrial background and orientation. The book is illustrated with numerous figures, photographs and schematic diagrams. http://rapidshare.de/files/7052446/fnbhb.rar.html or http://rapidshare.de/files/20325 ... _2nd_Ed__Noyes_.rar  General Contents: Fermentation Pilot Plant - Microbial Fermentation - Mammalian Cell Culture System - Bioreactors for Plant Cell Tissue and Organ Cultures Fermentation Design - Fermentation Department, Equipment and Space Requirements - General Design Data - Continuous Sterilizers - Fermeter Cooling - The Design of Large Fermenters (Based on Aeration) - Trouble Shooting in a Fermentation Plant Nutritional Requirements in Fermentation Processes - Nutritional Requirements of the Cell - The Carbon Source - The Nitrogen and Sulfur Source - The Source of Trace and Esssential Elements - The Vitamin Source and Other Growth Factors - Physical and Ionic Requirements - Media Development - Effect of Nutrient Concentration on Growth Rate Statistical Methods for Fermentation Optimization - Traditional One-Variable-At-A-Time Method - Evolutionary Optimization - Response Surface Methodology - Advantages of RSM - Disadvantages of RSM - Potential Difficulties with RSM - Methods to Improve the RSM Model Agitation - Theory and Concepts - Pumping Capacity and Fluid Shear Rates - Mixers and Impellers - Baffles - Fluid Shear Rates - Full-Scale Plant Design - Full Scale Process Example - The Role of Cell Concentration on Mass Transfer Rate - Some Other Mass Transfer Considerations - Design Problems in Biochemical Engineering - Solution-Fermentation Problems Filtration - Cake Filtration - Theory - Particle Size Distribution - Optimal Cake Thickness - Filter Aid - Filter Media - Equipment Selection - Continuous vs. Batch Filtration - Rotary Vacuum Drum Filter - Nutsches - HP-Hybrid Filter Press - Manufacturers Cross-Flow Filtration - Cross-Flow vs. Dead End Filtration - Comparison of Cross-Flow with Other Competing Technologies - Operating Configurations - Process Design Aspects - Applications Overview Solvent Extraction - Extraction Concepts - Distribution Data - Solvent Selection - Calculation Procedures - Drop Mechanics - Types of Extraction Equipment - Selection Equipment Ion Exchange - Theory - Ion Exchange Materials and Their Properties - Laboratory Evaluation of Resin - Process Considerations - Ion Exchange Operations - Industrial Chromatographic Operations Evaporation - Evaporators and Evaporation Systems - Liquid Characteristics - Heat Transfer in Evaporators - Evaporator Types - Energy Considerations for Evaporation System Design - Process Control Systems for Evaporators - Evaporator Performance - Heat Sensitive Products - Installation of Evaporators - Troubleshooting Evaporation Systems Crystallization - Theory - Crystallization Equipment - Data Needed for Design - Special Considerations for Fermentation Processes - Method of Calculation - Troubleshooting Centrifugation - Theory - Equipment Selection - Components of the Centrifuge - Sedimentation Centrifuges - Tubular-Bowl Centrifuges - Continuous Decanter Centrifuges (With Conveyor) - Disk Centrifuges - Filtering Centrifuges vs. Semimentation Centrifuges - Filtering Centrifuges - Vertical Basket Centrifuges - Horizontal Peeler Centrifuge - Inverting Filter Centrifuge - Maintance: Centrifuge - Safety - Pressure-Added Centrifugation - Manufaturers Water Systems for Pharmaceutical Facilities - Scope - Source of Water - Potable Water - Water Pretreatment - Multimedia Filtration - Water Softening - Activated Carbon - Ultraviolet Purification - Deionization - Purified Water - Reverse Osmosis - Water for Injection - Water System Documentation Sterile Formulation - Sterile Bulk Preparation - Isolation of Sterile Bulk Product - Crystallization - Filtering/Drying - Milling/Blending - Bulk Freeze Drying - Spray Drying - Equipment Preparation - Validation - Filling Vials with Sterile Bulk Materials - Environment - Equipment List Environmental Concerns - Environmental Regulations and Technology - Laws, Regulations and Permits - Technology (Waste Water) - Waste Water Treatments Strategy - Air (Emissions of Concern) - Selecting a Control Technology - Volatile Organic Compound (VOC) Emissions Control - Particulate Control - Inorganics Instrumentation and Control Systems - Measurement Technology - Biosensors - Cell Mass Measurement - Chemical Composition - Dissolved Oxygen - Exhaust Gas Analysis - Measurement of pH - Water Purity - Temperature - Pressure - Mass - Mass Flow Rate - Volumetric Flow Rate - Broth Level - Regulatory Control - Dynamic Modeling - Multivariable Control - Artificial Intelligence - Distributed Control Systems Drying (Indirect Drying) - Theory - Equipment Selection - Equipment Manufacturers - Directory of Manufactures (Direct Drying) - Definitions - Psychrometric Charts - Drying Theory - Fundamental Aspects Dryer Selection - Data Requirements - Sizing Dryers - Safety Issues - Decisions - Troubleshooting Guide - Recommended vendor List Plant Design and Cost - Introduction to the Capital Project Life Cycle - Conceptual Phase - Preliminary Design Phase - Detail Design Phase - Construction Phase - Start-Up Phase - The Fast Track Concept - The Impact of Validation - Introduction to the Costing of a Capital Project - Order of Magnitude Estimate - Approval Grade Estimate - Control Estimate - Dynamics of an Estimate |
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