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【答案】应助回帖
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sltmac(金币+2): 感谢应助~ 2011-07-27 00:04:13
sltmac(金币+50): 2011-08-05 15:17:02
sltmac(金币+40, 翻译EPI+1): 感谢应助，欢迎常来~~ 2011-08-05 15:17:17
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Drug A has the effect to induce autophagy.Autophagy has drawn great attention in research community in recent years.In the normal multi-cellular organisms，during the process of energy metabolism and biological activities ,there will produce some unnecessary organelles or proteins as well as metabolites and autophagy can play a pivotal role in clearing up such wastes in order to provide energy for the normal cellular functions.And once there is something wrong with the autophagy，some normal cellular processes will fail .Just as that the accumulated errors to a delicately regulated program will result in systematic problems ,the abnormality with autophagy can led to increased likelihood for the spontaneous tumorigenesis.Now,amounting evidence shows that there is close association between autophagy defect and tumorigenesis One study showed that in the heterozygous autophagy gene Beclin-1 mice,the odds of spontaneous malignancies increased and other studies demonstrated that the probability of loss of allelic Beclin-1 is higher in the breast cancer ,ovary cancer ,prostate cancer and leukemia patients than in the otherwise healthy control population.Drug A can be extracted from medicinal herbs and has anti-cancer effects but the specific mechanism for its anti-cancer effects is rarely studied.The autophagy can be a novel target and direction for the study of anti-cancer role of drug A. |
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