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美国癌研所（National Cancer Institute,NCI)肿瘤药理学实验方法进展
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美国癌研所（National Cancer Institute,NCI)肿瘤药理学实验方法进展 1.Preclinical models in cancer drug discovery and development 2. Update on NCI in vitro drug screen utilities 3. In vitro modelling of human tumour behaviour in drug discovery programmes 4. Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery 5. The hollow fibre model in cancer drug screening: the NCI experience 6. "Of mice and men": values and liabilities of the athymic nude mouse model in anticancer drug development 7. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development 8. In vivo models for endocrine-dependent breast carcinomas: special considerations of clinical relevance 9. Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages 10.Spontaneous and genetically engineered animal models: use in preclinical cancer drug development 11. Modelling approaches for angiogenesis 12. A potential role for imaging technology in anticancer efficacy evaluations 13. The Cancer Research UK experience of pre-clinical toxicology studies to support early clinical trials with novel cancer therapies 14. Multi-species toxicology approaches for oncology drugs: the US perspective |
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