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烟云听雨铁杆木虫 (正式写手)
金虫
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[求助]
求翻译一段英文文献(有机化学)
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In addition to their potential as an antitussive target, Sig-Rs have been implicated in a wide range of physiological functions and thus represent a unique therapeutic target for disorders such as depression, schizophrenia, and Parkinson’s disease (41–44). Although the precise role of Sig-Rs is not well understood, it is widely believed that the effects of Sig-Rs can be attributed to their modulation of other receptor types. This neuromodulatory role has complicated research on Sig-Rs and underscores the benefit of finding new compounds to modulate these receptors and probe their function (43, 44). Table 1 summarizes the overall yields for the initial library efforts as well as exploratory screening for κ opioid receptor (KOR), sigma 1, and sigma 2 receptor binding (Ki values) for these compounds. |
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考博求助
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8814402
至尊木虫 (职业作家)
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【答案】应助回帖
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In addition to their potential as an antitussive target, Sig-Rs have been implicated in a wide range of physiological functions and thus represent a unique therapeutic target for disorders such as depression, schizophrenia, and Parkinson’s disease (41–44). Although the precise role of Sig-Rs is not well understood, it is widely believed that the effects of Sig-Rs can be attributed to their modulation of other receptor types. This neuromodulatory role has complicated research on Sig-Rs and underscores the benefit of finding new compounds to modulate these receptors and probe their function (43, 44). Table 1 summarizes the overall yields for the initial library efforts as well as exploratory screening for κ opioid receptor (KOR), sigma 1, and sigma 2 receptor binding (Ki values) for these compounds. 126词=50金币！ |
3楼2011-07-19 10:50:11
8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
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- 专业: 药物学其他科学问题
2楼2011-07-19 08:13:11
8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
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| In addition to their potential as an antitussive target, Sig-Rs have been implicated in a wide range of physiological functions and thus represent a unique therapeutic target for disorders such as depression, schizophrenia, and Parkinson’s disease (41–44). 除了作为潜在的镇咳靶标，Sig-R与许多生理功能相关，因而有可能作为某些疾病如抑郁症、精神分裂症和帕金森氏病等的治疗靶标。 |
4楼2011-07-19 16:47:39
8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
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- 金币: 12921.1
- 散金: 47
- 红花: 16
- 帖子: 4185
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- 虫号: 1184404
- 注册: 2011-01-06
- 专业: 药物学其他科学问题
★ ★
Mally89(金币+2): 感谢应助！~辛苦了！~ 2011-07-23 22:09:02
Mally89(金币+2): 感谢应助！~辛苦了！~ 2011-07-23 22:09:02
| Although the precise role of Sig-Rs is not well understood, it is widely believed that the effects of Sig-Rs can be attributed to their modulation of other receptor types. 尽管对于Sig-R的明确角色尚未完全阐明，但比较公认的是Sig-R的效应可以归结于它们对其他受体类型的调节。This neuromodulatory role has complicated research on Sig-Rs and underscores the benefit of finding new compounds to modulate these receptors and probe their function (43, 44). Sig-R这种神经调节角色的复杂研究凸显发现的能够调节这些受体并探索这些受体功能的新化合物的益处。Table 1 summarizes the overall yields for the initial library efforts as well as exploratory screening for κ opioid receptor (KOR), sigma 1, and sigma 2 receptor binding (Ki values) for these compounds.表1总结了这些化合物的初期文库工作以及针对κ阿片受体、sigma 1和sigma 2受体结合的试验筛选的整体状况。 |
5楼2011-07-19 17:05:12
