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The diversity oriented synthetic approach employed a threephase approach called build/couple/pair (B/C/P). The first step ¨C the build phase ¨C required the acquisition of stereochemically defined building blocks with suitable functionality for coupling. The building blocks were coupled to generate all possible stereoisomers, and in the final pair phase, the linear precursors were intramolecularly cyclised to give a diversity of ring systems. This approach gave access to both medium-sized (8¨C9 atom) ring systems and macrocycles with 12¨C14 atoms. As an illustration, all stereoisomers of the building blocks 1 and 2 were generated (the latter by stereocontrolled aldol condensations), and combined to give all 8 stereoisomers of the dimer 3. Medium-sized rings (4)and macrocycles (5 and 6) were generated by nucleophilic aromatic substitution, Huisgen [3 + 2] cycloaddition and ring-closing metathesis (RCM) reactions. |
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ky888(½ð±Ò+10, ·ÒëEPI+1): ºÜ¸øÁ¦°¡ ллÀ² 2011-07-02 01:58:37
Mally89(½ð±Ò+2): ¸ÐлӦÖú£¡~»¶Ó³£À´£¡~ 2011-07-04 16:50:14
ky888(½ð±Ò+10, ·ÒëEPI+1): ºÜ¸øÁ¦°¡ ллÀ² 2011-07-02 01:58:37
Mally89(½ð±Ò+2): ¸ÐлӦÖú£¡~»¶Ó³£À´£¡~ 2011-07-04 16:50:14
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