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We introduced morpholine to form hydrogen bonds with Glu-61 in the c-subunit of ATP synthase and prevent proton transport which is necessary for the synthesis of ATP .£¨¼ÓЩʲôʹÆäÁ¬¹áÄØÕâÀWe introduced adamantine to get better lipophilicity and selectivity. дÎÄÕÂÖÐÒ»¾ä»°£¬Ôõô¿´Ôõô±ðŤ¡£Í¶SCIÎÄÕÂÓá£ÁíÓн¨Òé¿É¼Ó½±°¡ 1Ôõô°ÑÕⶨÓï´Ó¾äwhichÈ¥µôÄØ£¬µ«Òâ˼²»±ä¡£ 2 ¼ÓµãʲôʹÆäÁ¬¹áÄØ£¿ ´óÖÂÖÐÎÄÄÚÈÝ£º ÎÒÃÇÒýÈëÂðßø»ù£¬Ê¹ÆäÓëATPºÏ³ÉøÀïµÄ¸Ê°±ËáÐγÉÇâ¼ü ×èÖ¹Çâ×ªÒÆ¡£¸ÃÇâ×ªÒÆÊǺϳÉATPµÄ±ØÐ벿·Ö¡£ÎÒÃÇÒýÈë½ð¸ÕÍé»ùÊÇΪÁ˵õ½¸üºÃµÄÖ¬ÈÜÐÔºÍÑ¡ÔñÐÔ¡£ |
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baiyuefei(½ð±Ò+15, ·ÒëEPI+1): 2011-06-27 17:17:04
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½é´ÊÊǺܺÃÓõÄÊֶΣº We introduced morpholine to form hydrogen bonds with Glu-61 in the c-subunit of ATP synthesis and prevent proton transport. However, the proton transport is a necessary (and important) step in the synthesis of ATP. Therefore, we introduced adamantine to get better lipophilicity and selectivity. |
2Â¥2011-06-27 17:06:30
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3Â¥2011-06-27 17:07:56
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4Â¥2011-09-04 22:43:43














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