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【答案】应助回帖
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xuemei1984(金币+3, 翻译EPI+1): 谢谢，翻译的很好！ 2011-06-25 12:29:05
Mally89(金币+1): 感谢应助！~ 2011-06-25 22:03:50
1)It is tempting to speculate that the physical location of miR-15/16 and miR-103/107, along with their known overlap in targets, provides clues indicating that these genes serve functional roles linked to a cross-talk between the key cellular functions of cell division and of metabolism. miR-15/16 和 miR-103/107的物理位置，会同它们已知的与靶标的重叠，将提供这些基因与细胞分化和代谢间交互调节相联系的功能角色的线索，只是一个有吸引力的推断。
2)For these experiments, an individual mRNA was considered to be a target of miRNA X if the level of that mRNA was significantly reduced following a miRNA transfection with miRNA X, relative to the level of that mRNA after transfection with a negative control miRNA.在这些试验中，如果一个mRNA的水平在以miRNA X转染后相对于以阴性质控miRNA转染后显著降低，则此单个mRNA可被作为miRNA X的一个靶标。
3)miR-103/107 paralogs and PANK genes may be coordinately transcribed gene products with synergistic effects on the regulation of cellular acetyl-CoA levels. miR-103/107旁系同源和泛酰酸激酶基因可能同样被转录为在调控细胞乙酰辅酶A水平上具有协同效应的基因产物。 |
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