| 查看: 187 | 回复: 0 | ||
烟云听雨铁杆木虫 (正式写手)
金虫
|
[求助]
求翻译一段英文文献（药化）
|
|
Three potent Sig-R binding compounds—10{20}, 10{22}, and 10{7} (which contains two basic nitrogen atoms)—were evaluated for their GPCR selectivity against 38 targets, and the results were incorporated in Table 1 (see SI Appendix for a heat map– formatted selectivity table). The three compounds displayed >86∶1 selectivities for the limited number of receptors for which binding was observed at all; an impressive result for compounds obtained in such an abbreviated structure-activity optimization exercise. The N-propyl derivative 10{22}, designed to eliminate binding arising from a pendant aryl-containing side chain, was particularly selective. Here, the only non-Sig-R binding was detected against the 5HT1A receptor (Ki ¼ 4;500 nM) as opposed to Sig-R 1 and Sig-R 2 (Ki values of 12 and 288 nM, respectively), |
回复此楼» 猜你喜欢
0703 总分319求调剂
已经有3人回复
-
化工京区271求调剂
已经有5人回复
-
欢迎采矿、地质、岩土、计算机、人工智能等专业的同学报考
已经有8人回复
-
化学，材料，环境类求调剂
已经有4人回复
-
接收调剂
已经有12人回复
-
085600求调剂
已经有3人回复
-
考研复试调剂，过国家线的同学都可报名
已经有5人回复
-
085600 英一数二272求调剂
已经有13人回复
-
理学，工学，农学调剂，少走弯路，这里欢迎您！
已经有5人回复
-
一志愿华南理工大学材料与化工326分，求调剂
已经有3人回复
