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We therefore did not feel constrained in the range of chemical manipulations we could explore, and in many cases the final compounds bear little resemblance to any known Stemona alkaloid. Herein, we report the initial evaluation of these compounds against a panel of G protein-coupled receptor (GPCR) targets relevant to central nervous system function and how those results have inspired additional library design, ultimately resulting in a series of highly potent Sig-R ligands. |
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