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We therefore did not feel constrained in the range of chemical
manipulations we could explore, and in many cases the final compounds
bear little resemblance to any known Stemona alkaloid.
Herein, we report the initial evaluation of these compounds
against a panel of G protein-coupled receptor (GPCR) targets
relevant to central nervous system function and how those results
have inspired additional library design, ultimately resulting in a
series of highly potent Sig-R ligands.

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