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烟云听雨铁杆木虫 (正式写手)
金虫
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[求助]
求翻译一段英文（药化）
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The extracts of stemonaceous flora have been utilized for centuries as treatments for respiratory ailments in established Asian traditions. Additional effects associated with these plants (or discrete compounds isolated from them) include insecticidal, anthelmintic, antitussive, and various neurochemical actions (11–17), although the molecular mechanisms responsible for their activities have rarely been identified (18). Four structurally related isolated Stemona alkaloid molecules are depicted in Fig. 1. The reported antitussive activities of two isolated Stemona alkaloid compounds, neostenine 3 and neotuberostemonine 4 against citric acid-induced cough in guinea pig animal models have validated the traditional medicine uses for these plants (19, 20). More recently, antitussive activity has been confirmed for additional isolated Stemona alkaloid compounds (21–23).The diversity of reported traditional uses combined with demonstrated in vivo activity of several members supported the pursuit of an appropriately simplified Stemona alkaloid structure for speculative screening. |
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chzhbin
金虫 (职业作家)
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【答案】应助回帖
★ ★
ringzhu(金币+1): 多谢交流 欢迎常来 端午快乐~~ 2011-06-06 15:36:40
sltmac(金币+1): 谢谢交流~~ 2011-06-06 18:18:48
烟云听雨(金币+15, 翻译EPI+1): 谢谢 2011-06-06 18:46:09
ringzhu(金币+1): 多谢交流 欢迎常来 端午快乐~~ 2011-06-06 15:36:40
sltmac(金币+1): 谢谢交流~~ 2011-06-06 18:18:48
烟云听雨(金币+15, 翻译EPI+1): 谢谢 2011-06-06 18:46:09
| 在亚洲人的传统中，stemonaceous 群提取物被用来治疗呼吸系统疾病有几个世纪之久，尽管活性的分子机制还没有得到证实，那些植物（分离出的化合物）还有杀虫、驱虫、止咳及许多影响神经系统的作用。图1中为分离出的四个结构相关的百部生物碱结构。neostenine 3和neotuberostemonine 4 对于柠檬酸所致的豚鼠咳嗽的止咳作用证实了这些植物的传统药用。最近，分离出的百部生物碱化合物21-23的止咳活性得到证实，传统应用的多样性以及已经证实的几个化合物的体内活性支持百部生物碱的结构适当简化以用来筛选! |
2楼2011-06-06 13:55:24
