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烟云听雨铁杆木虫 (正式写手)
金虫
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[求助]
求翻译一段英文文献（药化）
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The practical pursuit of such an approach presupposes efficient synthetic access to the desired scaffold, a prerequisite that might not be as straightforward as using the natural product itself as starting material. An attractive alternative is to build the proposed scaffold de novo, an activity that can be considerably informed by knowledge gained in natural products total synthesis [i.e., the “diverted chemical synthesis” concept elucidated by Wilson and Danishefsky (10)]. In this paper, we describe the use of such a strategy to identify several potent sigma receptor (Sig-R) ligands. The two key components of success were (i) efficient access to the lead natural products via total synthesis and (ii)the subsequent development of general synthetic methodology that allowed for systematic and flexible chemical optimizationof a core moiety |
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