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烟云听雨铁杆木虫 (正式写手)
金虫
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[求助]
求翻译摘要
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Reported biological activities of Stemona natural products, such as antitussive activity, inspired the development of synthetic methods to access several alkaloids within this family and in so doing develop a general route to the core skeleta shared by the class of natural products. The chemistry was subsequently adapted to afford a series of analogue sets bearing simplified, diverse Stemona-inspired skeleta. Over 100 of these analogues were subjected to general G protein-coupled receptor profiling along with the known antitussive compound, neostenine; this led to the identification of hit compounds targeting several receptor types. The particularly rich hit subset for sigma receptors was expanded with two focused library sets, which resulted in the discovery of a fully synthetic, potent chemotype of sigma ligands. This collaborative effort combined the development of synthetic methods with extensive, flexible screening resources and exemplifies the role of natural products in bioactivity mining. |
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1986
铁杆木虫 (知名作家)
药童
- 翻译EPI: 26
- 应助: 0 (幼儿园)
- 金币: 8305.5
- 散金: 43
- 红花: 7
- 沙发: 302
- 帖子: 5662
- 在线: 312.8小时
- 虫号: 1195378
- 注册: 2011-01-24
- 性别: GG
- 专业: 有机合成
【答案】应助回帖
★ ★
sltmac(金币+1): 谢谢交流~~ 2011-06-03 20:36:58
Mally89(金币+1): 蛮长的，再添一个！~ 2011-06-03 21:22:18
烟云听雨(金币+10, 翻译EPI+1): 谢谢 2011-06-04 11:11:37
sltmac(金币+1): 谢谢交流~~ 2011-06-03 20:36:58
Mally89(金币+1): 蛮长的，再添一个！~ 2011-06-03 21:22:18
烟云听雨(金币+10, 翻译EPI+1): 谢谢 2011-06-04 11:11:37
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Reported biological activities of Stemona natural products, such asantitussive activity, inspired the development of synthetic methodsto access several alkaloids within this family and in so doing developa general route to the core skeleta shared by the class of naturalproducts. 报道的百部属中有生物活性的天然产物，例如，有镇咳活性的化合物，启发了本属中几个生物碱的合成方法，并发展了一条常规合成这些天然产物核心结构的方法。 The chemistry was subsequently adapted to afford a seriesof analogue sets bearing simplified, diverse Stemona-inspiredskeleta. 随后化学发展了一系列的类似的简化了类似的关系集合。 Over 100 of these analogues were subjected to generalG protein-coupled receptor profiling along with the known antitussivecompound, neostenine; this led to the identification ofhit compounds targeting several receptor types. 超过100种类似物围绕已知的镇咳活性化合物neostenine的结构在一起组成了G蛋白偶联受体，从而鉴定出药物是进攻那种受体。 The particularlyrich hit subset for sigma receptors was expanded with two focusedlibrary sets, which resulted in the discovery of a fully synthetic,potent chemotype of sigma ligands. 明确地，饱和对 σ-受体的进攻延伸到两个专注的集合库，从而发现了一个完整的合成物：强效的σ-配体。 This collaborative effortcombined the development of synthetic methods with extensive,flexible screening resources and exemplifies the role of natural productsin bioactivity mining. 这种协作的，混合的合成法的发现可以广泛的，灵活的筛选资源，并且例证天然产物的生物活性。 |
2楼2011-06-03 12:43:02
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