| 查看: 516 | 回复: 1 | ||
| 【奖励】 本帖被评价1次，作者城堡betty增加金币 0.8 个 | ||
[资源]
传统实验小鼠缺乏遗传多样性 科学家引进野生小鼠后代
|
||
|
转自：http://news.biodiscover.com 遗传变化被认为是导致癌症，心脏病等部分疾病的原因。而目前的实验鼠缺乏遗传多样性，研究人员开始利用野生小鼠后代作为实验鼠，试克服有限的遗传多样性有关的问题。 Laboratory research has always been limited in terms of what conclusions scientists can safely extrapolate from animal experiments to the human population as a whole. Many promising findings in mice have not held up under further experimentation, in part because laboratory animals, bred from a limited genetic foundation, don't provide a good representation of how genetic diversity manifests in the broader human population. Now, thanks to an in-depth analysis by a team led by Fernando Pardo-Manuel de Villena, PhD, in the UNC Department of Genetics and Gary Churchill, PhD, at The Jackson Laboratory in Bar Harbor, Maine, researchers will be able to use an online resource dubbed the Mouse Phylogeny Viewer to select from among 162 strains of laboratory mice for which the entire genome has been characterized. Phylogeny refers to the connections among all groups of organisms as understood by ancestor/descendant relationships. Pardo-Manuel de Villena is also a member of UNC Lineberger Comprehensive Cancer Center and the Carolina Center for Genome Sciences. The results of the analysis that make this tool possible were published online today in the journal Nature Genetics. "The viewer provides scientists with a visual tool where they can actually go and look at the genome of the mouse strains they are using or considering, compare the differences and similarities between strains and select the ones most likely to provide the basis for experimental results that can be more effectively extrapolated to the diverse human population," said Pardo-Manuel de Villena. "As scientists use this resource to find ways to prevent and treat the genetic changes that cause cancer, heart disease, and a host of other ailments, the diversity of our lab experiments should be much easier to translate to humans," he noted. He explains that the DNA of a given pair of typical laboratory mouse strains varies in only half of their genome and captures less than 20 percent of the diversity of the entire mouse genome. Historically, biomedical researchers have relied on what are called classical inbred strains of mice in laboratory research. With the advance of genetic science, researchers began to use wild-derived laboratory strains (descendants of captured wild mice that originate from a small number of original ancestors) to try to overcome issues associated with limited genetic diversity. However, scientists' understanding of genetic diversity in mice has – until now – been limited and biased toward the most frequently used strains. The team compared the genome of a large and diverse sample including 36 strains of wild-caught mice, 62 wild-derived laboratory strains and 100 classical strains obtained from different stocks and different laboratories using the Mouse Diversity array – a technology that maps the entire mouse genome. Their analysis exponentially increases the data available to geneticists who work with mice, allowing them to statistically impute the whole mouse genome sequence with very high accuracy for hundreds of laboratory mouse strains – leading to much greater precision in the interpretation of existing biomedical data and optimal selection of strains in future experiments. |
回复此楼» 猜你喜欢
江苏省优青门槛
已经有20人回复
-
心好累。今年我们部门提交了18个项目。中了11了，可惜我的又挂了
已经有10人回复
-
植物学论文润色/翻译怎么收费?
已经有206人回复
-
面上项目计划书
已经有7人回复
-
面上项目计划书附件
已经有9人回复
-
面上项目计划书系统状态
已经有18人回复
-
NSFC-UNEP（与联合国环境规划署）合作项目
已经有33人回复
-
和伊朗人合作
已经有32人回复
-
江苏省自然基金
已经有8人回复
-
生命科学新英文普刊《INVESTIGATION OF LIFE SCIENCE》
已经有11人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 种群遗传多样性实验
已经有6人回复
- 小鼠遗传学的两个问题!求助
已经有6人回复
- 请教一处雄性小鼠解剖结构
已经有6人回复
- 请求大家给推荐几个1一下的期刊啊
已经有15人回复
- 北京大学生物医学工程系招聘生物实验技术员
已经有4人回复
- 【求助/交流】分析野生大豆生物多样性该用什么方法？
已经有6人回复
- 【求助】蓝耳病毒 致病性！！！
已经有4人回复
2楼2011-05-31 12:35:51
20