|
|
¡¾´ð°¸¡¿Ó¦Öú»ØÌû
dahuihui(½ð±Ò+8, ·ÒëEPI+1): 2011-05-10 11:06:24
Further examination of the literature indicated that only a few reports of the Suzuki¨CMiyaura reaction of 2-pyridyl nucleophiles with aryl halides have appeared, and in these examples, only aryl iodides have been demonstrated as suitable coupling partners. The difficulty can be attrib-uted tos everal factors:1) Electron-deficient hetero aryl boron derivatives undergo transmetalation at a relatively slow rate, and 2) these reagents rapidly decompose by a protodeboro-nation pathway.
ÎÒÃDzéÔÄÁ˺ܶàÎÄÏ×£¬·¢ÏÖÓкÜÉÙµÄÎÄÏ×±¨µÀ2λßÁऻùµÄ±´ú·¼ÌþÄÜ·¢ÉúSuzuki¨CMiyaura żÁª·´Ó¦£¨Áåľ-¹¬ÆÖ·´Ó¦£©£¬²¢ÇÒÖ»Óеâ´ú·¼ÌþÄÜ×÷ΪºÏÊʵÄżºÏÌå¡£ÔÒò¿ÉÄÜÊÇ£º1£©µç×ÓȱʧµÄ·¼»ùÅðÑÜÉúÎï·¢ÉúÂýËٵķ´½ðÊô»¯×÷Óã»2£©ÕâЩÊÔ¼Á¾¹ýÅð»¯Ð§ÓÃѸËٷֽ⡣
ÓлúÒ©Æ··²»×¼£¬ÆÚ´ý¸ßÊÖ£¬ÐéÐÄѧϰ..... |
|