| 查看: 353 | 回复: 0 | |||
| 当前主题已经存档。 | |||
chendexin木虫 (正式写手)
|
[交流]
Research Reveals Faulty Biological Clock Genes Could Influence Addiction
|
||
|
Drug addiction exacts a variety of ill effects on a user's health. Among other things, addicts often experience disrupted sleep. The mechanism behind how the substances may change a user's circadian rhythms remains unknown but new research on mice is providing some insight. According to a report published online this week by the Proceedings of the National Academy of Sciences, circadian rhythm genes help to regulate the brain's reward system and could influence the addictive properties of drugs such as cocaine. Colleen A. McClung of the University of Texas Southwestern Medical Center and her colleagues studied mice lacking a circadian rhythm gene known as Clock. Compared to control animals, mice without Clock were hyperactive and became even more so after being given cocaine. What is more, they also found the drug more rewarding than normal mice did. Finally, Clock-deficient animals exhibited increased activity in the dopamine neurotransmitter system in the brain, which is heavily stimulated by cocaine use. "We found that the Clock gene is not only involved in regulating sleep/wake cycles, but is also very involved in regulating the rewarding responses to drugs of abuse," McClung says. The researchers plan to study human drug users next, to see if the new role for Clock also pertains to people. "Most work on Clock has focused on the brain's master pacemaker, located in a brain area called the suprachiasmatic nucleus," explains study co-author Eric J. Nestler, also at the University of Texas Southwestern Medical Center. "The novelty of [the] findings is the role Clock plays in brain reward pathways. The next step is to examine Clock and related genes in human addicts." --Sarah Graham |
回复此楼» 猜你喜欢
Suzuki偶联中硼酸酯原料掉下的硼酸酯是否可以自身偶联，生成B2Pin2杂质
已经有3人回复
-
2026年面上项目中了，2A+B, 会评顺利通过
已经有11人回复
-
大龄残疾硕士的一点执念
已经有19人回复
-
今年E04面上
已经有19人回复
-
刑法学论文投稿求助
已经有5人回复
-
Journal of Environmental Chemical Engineering
已经有3人回复
-
最后一年，祈求好运
已经有3人回复
-
风电环氧领域
已经有3人回复