| 查看: 342 | 回复: 0 | |||
| 当前主题已经存档。 | |||
chendexin木虫 (正式写手)
|
[交流]
Research Reveals Faulty Biological Clock Genes Could Influence Addiction
|
||
|
Drug addiction exacts a variety of ill effects on a user's health. Among other things, addicts often experience disrupted sleep. The mechanism behind how the substances may change a user's circadian rhythms remains unknown but new research on mice is providing some insight. According to a report published online this week by the Proceedings of the National Academy of Sciences, circadian rhythm genes help to regulate the brain's reward system and could influence the addictive properties of drugs such as cocaine. Colleen A. McClung of the University of Texas Southwestern Medical Center and her colleagues studied mice lacking a circadian rhythm gene known as Clock. Compared to control animals, mice without Clock were hyperactive and became even more so after being given cocaine. What is more, they also found the drug more rewarding than normal mice did. Finally, Clock-deficient animals exhibited increased activity in the dopamine neurotransmitter system in the brain, which is heavily stimulated by cocaine use. "We found that the Clock gene is not only involved in regulating sleep/wake cycles, but is also very involved in regulating the rewarding responses to drugs of abuse," McClung says. The researchers plan to study human drug users next, to see if the new role for Clock also pertains to people. "Most work on Clock has focused on the brain's master pacemaker, located in a brain area called the suprachiasmatic nucleus," explains study co-author Eric J. Nestler, also at the University of Texas Southwestern Medical Center. "The novelty of [the] findings is the role Clock plays in brain reward pathways. The next step is to examine Clock and related genes in human addicts." --Sarah Graham |
回复此楼» 猜你喜欢
一志愿中南化学337求调剂
已经有5人回复
-
281求调剂（0805）
已经有23人回复
-
265求调剂
已经有9人回复
-
279分求调剂 一志愿211
已经有10人回复
-
招收调剂硕士
已经有12人回复
-
296求调剂
已经有8人回复
-
招收博士1-2人
已经有3人回复
-
085700资源与环境308求调剂
已经有11人回复
-
274求调剂
已经有8人回复
-
290求调剂
已经有4人回复
